Sequence-analysis of monoclonal-antibody resistant mutants of type-O foot-and-mouth-disease virus - evidence for the involvement of the 3 surface exposed capsid proteins in 4 antigenic sites

J. D. A. Kitson; D. McCahon; Graham Belsham

doi:10.1016/0042-6822(90)90269-W

Sequence-analysis of monoclonal-antibody resistant mutants of type-O foot-and-mouth-disease virus - evidence for the involvement of the 3 surface exposed capsid proteins in 4 antigenic sites

J. D. A. Kitson, D. McCahon, Graham Belsham

Pirbright Institute

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Sequence analysis of monoclonal antibody resistant mutants of type O foot and mouth disease virus has been performed. Distinct clusters of amino acid substitutions conferring resistance to neutralization at each of the four previously defined antigenic sites (McCahon et al., 1989, J. Gen. Virol. 70, 639–645) have been identified. One site corresponds to the well-known 140–160 region of VP1, a second site is also on VP1, one site is on VP2, and the fourth site is on VP3. All of the amino acid substitutions identified are located on the surface of the virus. Despite the differences in three-dimensional structure between FMDV and other picornaviruses the neutralizing antigenic sites occur in analogous positions on the capsid surface.

Original language	English
Journal	Virology
Volume	179
Issue number	1
Pages (from-to)	26-34
ISSN	0042-6822
DOIs	https://doi.org/10.1016/0042-6822(90)90269-W
Publication status	Published - 1990
Externally published	Yes

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@article{de548fed076e45f4ac9ea836b04ffa76,

title = "Sequence-analysis of monoclonal-antibody resistant mutants of type-O foot-and-mouth-disease virus - evidence for the involvement of the 3 surface exposed capsid proteins in 4 antigenic sites",

abstract = "Sequence analysis of monoclonal antibody resistant mutants of type O foot and mouth disease virus has been performed. Distinct clusters of amino acid substitutions conferring resistance to neutralization at each of the four previously defined antigenic sites (McCahon et al., 1989, J. Gen. Virol. 70, 639–645) have been identified. One site corresponds to the well-known 140–160 region of VP1, a second site is also on VP1, one site is on VP2, and the fourth site is on VP3. All of the amino acid substitutions identified are located on the surface of the virus. Despite the differences in three-dimensional structure between FMDV and other picornaviruses the neutralizing antigenic sites occur in analogous positions on the capsid surface.",

author = "Kitson, \{J. D. A.\} and D. McCahon and Graham Belsham",

year = "1990",

doi = "10.1016/0042-6822(90)90269-W",

language = "English",

volume = "179",

pages = "26--34",

journal = "Virology",

issn = "0042-6822",

publisher = "Academic Press",

number = "1",

}

Sequence-analysis of monoclonal-antibody resistant mutants of type-O foot-and-mouth-disease virus - evidence for the involvement of the 3 surface exposed capsid proteins in 4 antigenic sites. / Kitson, J. D. A.; McCahon, D.; Belsham, Graham.
In: Virology, Vol. 179, No. 1, 1990, p. 26-34.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - Sequence-analysis of monoclonal-antibody resistant mutants of type-O foot-and-mouth-disease virus - evidence for the involvement of the 3 surface exposed capsid proteins in 4 antigenic sites

AU - Kitson, J. D. A.

AU - McCahon, D.

AU - Belsham, Graham

PY - 1990

Y1 - 1990

N2 - Sequence analysis of monoclonal antibody resistant mutants of type O foot and mouth disease virus has been performed. Distinct clusters of amino acid substitutions conferring resistance to neutralization at each of the four previously defined antigenic sites (McCahon et al., 1989, J. Gen. Virol. 70, 639–645) have been identified. One site corresponds to the well-known 140–160 region of VP1, a second site is also on VP1, one site is on VP2, and the fourth site is on VP3. All of the amino acid substitutions identified are located on the surface of the virus. Despite the differences in three-dimensional structure between FMDV and other picornaviruses the neutralizing antigenic sites occur in analogous positions on the capsid surface.

AB - Sequence analysis of monoclonal antibody resistant mutants of type O foot and mouth disease virus has been performed. Distinct clusters of amino acid substitutions conferring resistance to neutralization at each of the four previously defined antigenic sites (McCahon et al., 1989, J. Gen. Virol. 70, 639–645) have been identified. One site corresponds to the well-known 140–160 region of VP1, a second site is also on VP1, one site is on VP2, and the fourth site is on VP3. All of the amino acid substitutions identified are located on the surface of the virus. Despite the differences in three-dimensional structure between FMDV and other picornaviruses the neutralizing antigenic sites occur in analogous positions on the capsid surface.

U2 - 10.1016/0042-6822(90)90269-W

DO - 10.1016/0042-6822(90)90269-W

M3 - Journal article

SN - 0042-6822

VL - 179

SP - 26

EP - 34

JO - Virology

JF - Virology

IS - 1

ER -

Sequence-analysis of monoclonal-antibody resistant mutants of type-O foot-and-mouth-disease virus - evidence for the involvement of the 3 surface exposed capsid proteins in 4 antigenic sites

Abstract

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