Separation of xylose and glucose using an integrated membrane system for enzymatic cofactor regeneration and downstream purification

Sofie Thage Morthensen, Sigyn Björk Sigurdardóttir, Anne S. Meyer, Henning Jørgensen, Manuel Pinelo

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Mixtures of xylose, glucose and pyruvate were fed to a membrane bioreactor equipped with a charged NF membrane (NTR 7450). Value-added products were obtained in the reactor via enzymatic cofactor-dependent catalysis of glucose to gluconic acid and pyruvate to lactic acid, respectively. The initial cofactor (NADH) concentration could be decreased to 10% of the stoichiometric value (relative to glucose) without compromising process time and substrate conversion via i) efficient cofactor regeneration and ii) high retention of cofactor (R=0.98) in the membrane bioreactor. Furthermore, accumulation of xylose (R
Original languageEnglish
JournalJournal of Membrane Science
Volume523
Pages (from-to)327-335
ISSN0376-7388
DOIs
Publication statusPublished - 2017

Keywords

  • Biorefinery products
  • Cofactor regeneration
  • Membrane bioreactor
  • Nanofiltration
  • Sugars

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