Separation enhancement in pinched flow fractionation

Asger Laurberg Vig, Anders Kristensen

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    A method for enhancing the separation in the microfluidic size separation technique called pinched flow fractionation (PFF) is demonstrated experimentally and analyzed by numerical calculations. The enhancement is caused by a geometrical modification of the original PFF design. Seven different polystyrene bead sizes ranging from 0.25 to 2.5 mu m in radius were separated in a PFF and in an enhanced PFF device. The separation in the two types of devices were compared and an amplification in the separation of up to 70% was achieved. Numerical calculations, which include an edge effect, are used to analyze the device.
    Original languageEnglish
    JournalApplied Physics Letters
    Issue number20
    Pages (from-to)203507
    Publication statusPublished - 2008

    Bibliographical note

    Copyright (2008) American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics.


    • microfluidics
    • laminar flow
    • channel flow


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