Separation enhancement  in pinched flow  fractionation

Asger Laurberg Vig; Anders Kristensen

doi:10.1063/1.3028652

Separation enhancement in pinched flow fractionation

Asger Laurberg Vig, Anders Kristensen

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Abstract

A method for enhancing the separation in the microfluidic size separation technique called pinched flow fractionation (PFF) is demonstrated experimentally and analyzed by numerical calculations. The enhancement is caused by a geometrical modification of the original PFF design. Seven different polystyrene bead sizes ranging from 0.25 to 2.5 mu m in radius were separated in a PFF and in an enhanced PFF device. The separation in the two types of devices were compared and an amplification in the separation of up to 70% was achieved. Numerical calculations, which include an edge effect, are used to analyze the device.

Original language	English
Journal	Applied Physics Letters
Volume	93
Issue number	20
Pages (from-to)	203507
ISSN	0003-6951
DOIs	https://doi.org/10.1063/1.3028652
Publication status	Published - 2008

Bibliographical note

Copyright (2008) American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics.

Keywords

microfluidics
laminar flow
channel flow

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10.1063/1.3028652

AsgerFinal published version, 432 KB

http://link.aip.org/link/APPLAB/v93/i20/p203507/s1

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