Separation and recovery of intracellular betacarotene using a process synthesis framework

Alexander M.  Sabol; Maria-Ona Bertran; Jonathan P.  Raftery; John M. Woodley; Rafiqul Gani; M.  Nazmul Karima

doi:10.1016/B978-0-444-63965-3.50477-3

Separation and recovery of intracellular betacarotene using a process synthesis framework

Alexander M. Sabol, Maria-Ona Bertran, Jonathan P. Raftery, John M. Woodley, Rafiqul Gani, M. Nazmul Karima

Texas A&M University

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

Abstract

In this work, the process synthesis problem for the bio-manufacturing of high-value intracellular compounds is addressed using a systematic framework that allows for the user to input key process parameters from literature or experiments. The framework is based on a superstructure optimization approach and integrates various methods and tools, including a generic model and a database for data management (Bertran et al.,2017). We propose the following five steps: (1) problem formulation, (2) data collection and superstructure generation, (3) solution of the optimization problem, and (4) sensitivity analysis and (5) experimentation with informed design and then determination of the optimal process design. The framework is implemented in Super-O, software which guides the user through the formulation and solution of synthesis problems. This paper demonstrates the proposed framework though an illustrative case study on the production of beta-carotene from recombinant Saccharomyces cerevisiae(SM14) via continuous cultivation.

Original language	English
Title of host publication	Proceedings of the 27th European Symposium on Computer Aided Process Engineering (ESCAPE 27)
Editors	Antonio Espuña, Moisès Graells, Luis Puigjaner
Volume	40
Publisher	Elsevier
Publication date	2017
Edition	1
Pages	2851-2856
ISBN (Print)	9780444639653
ISBN (Electronic)	9780444639707
DOIs	https://doi.org/10.1016/B978-0-444-63965-3.50477-3
Publication status	Published - 2017
Event	27th European Symposium on Computer Aided Process Engineering - Barcelona, Spain Duration: 1 Oct 2017 → 5 Oct 2017 Conference number: 27 https://www.elsevier.com/books/27th-european-symposium-on-computer-aided-process-engineering/espuna/978-0-444-63965-3

Conference

Conference	27th European Symposium on Computer Aided Process Engineering
Number	27
Country/Territory	Spain
City	Barcelona
Period	01/10/2017 → 05/10/2017
Internet address	https://www.elsevier.com/books/27th-european-symposium-on-computer-aided-process-engineering/espuna/978-0-444-63965-3

Keywords

Process synthesis
Superstructure optimization
Downstream processing
Intracellular product
Bioprocess design
Bioseparations

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10.1016/B978-0-444-63965-3.50477-3

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Sabol, A. M., Bertran, M.-O., Raftery, J. P., Woodley, J. M., Gani, R., & Nazmul Karima, M. (2017). Separation and recovery of intracellular betacarotene using a process synthesis framework. In A. Espuña, M. Graells, & L. Puigjaner (Eds.), Proceedings of the 27th European Symposium on Computer Aided Process Engineering (ESCAPE 27) (1 ed., Vol. 40, pp. 2851-2856). Elsevier. https://doi.org/10.1016/B978-0-444-63965-3.50477-3

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Sabol, AM, Bertran, M-O, Raftery, JP, Woodley, JM, Gani, R & Nazmul Karima, M 2017, Separation and recovery of intracellular betacarotene using a process synthesis framework. in A Espuña, M Graells & L Puigjaner (eds), Proceedings of the 27th European Symposium on Computer Aided Process Engineering (ESCAPE 27). 1 edn, vol. 40, Elsevier, pp. 2851-2856, 27th European Symposium on Computer Aided Process Engineering, Barcelona, Spain, 01/10/2017. https://doi.org/10.1016/B978-0-444-63965-3.50477-3

Separation and recovery of intracellular betacarotene using a process synthesis framework. / Sabol, Alexander M. ; Bertran, Maria-Ona; Raftery, Jonathan P. et al.
Proceedings of the 27th European Symposium on Computer Aided Process Engineering (ESCAPE 27). ed. / Antonio Espuña; Moisès Graells; Luis Puigjaner. Vol. 40 1. ed. Elsevier, 2017. p. 2851-2856.

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

TY - GEN

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AU - Sabol, Alexander M.

AU - Bertran, Maria-Ona

AU - Raftery, Jonathan P.

AU - Woodley, John M.

AU - Gani, Rafiqul

AU - Nazmul Karima, M.

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AB - In this work, the process synthesis problem for the bio-manufacturing of high-value intracellular compounds is addressed using a systematic framework that allows for the user to input key process parameters from literature or experiments. The framework is based on a superstructure optimization approach and integrates various methods and tools, including a generic model and a database for data management (Bertran et al.,2017). We propose the following five steps: (1) problem formulation, (2) data collection and superstructure generation, (3) solution of the optimization problem, and (4) sensitivity analysis and (5) experimentation with informed design and then determination of the optimal process design. The framework is implemented in Super-O, software which guides the user through the formulation and solution of synthesis problems. This paper demonstrates the proposed framework though an illustrative case study on the production of beta-carotene from recombinant Saccharomyces cerevisiae(SM14) via continuous cultivation.

KW - Process synthesis

KW - Superstructure optimization

KW - Downstream processing

KW - Intracellular product

KW - Bioprocess design

KW - Bioseparations

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DO - 10.1016/B978-0-444-63965-3.50477-3

M3 - Article in proceedings

SN - 9780444639653

VL - 40

SP - 2851

EP - 2856

BT - Proceedings of the 27th European Symposium on Computer Aided Process Engineering (ESCAPE 27)

A2 - Espuña, Antonio

A2 - Graells, Moisès

A2 - Puigjaner, Luis

PB - Elsevier

T2 - 27th European Symposium on Computer Aided Process Engineering

Y2 - 1 October 2017 through 5 October 2017

ER -

Sabol AM, Bertran MO, Raftery JP, Woodley JM, Gani R, Nazmul Karima M. Separation and recovery of intracellular betacarotene using a process synthesis framework. In Espuña A, Graells M, Puigjaner L, editors, Proceedings of the 27th European Symposium on Computer Aided Process Engineering (ESCAPE 27). 1 ed. Vol. 40. Elsevier. 2017. p. 2851-2856 doi: 10.1016/B978-0-444-63965-3.50477-3

Separation and recovery of intracellular betacarotene using a process synthesis framework

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Keywords

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