Sensitivity to Lovastatin of Saccharomyces cerevisiae Strains Deleted for Pleiotropic Drug Resistance (PDR) Genes

Luca Riccardo Formenti, Morten Kielland-Brandt

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    Abstract

    The use of statins is well established in human therapy, and model organisms such as Saccharomyces cerevisiae are commonly used in studies of drug action at molecular and cellular levels. The investigation of the resistance mechanisms towards statins may suggest new approaches to improve therapy based on the use of statins. We investigated the susceptibility to lovastatin of S. cerevisiae strains deleted for PDR genes, responsible for exporting hydrophobic and amphi-philic drugs, such as lovastatin. Strains deleted for the genes tested, PDR1, PDR3, PDR5 and SNQ2, exhibited remarkably different phenotypes, with deletion of PDR5 causing the highest sensitivity to lovastatin. The study helped clarifying which pdr mutants to use in studies of physiological actions of statins in yeast. Copyright (C) 2011 S. Karger AG, Basel
    Original languageEnglish
    JournalJournal of Molecular Microbiology and Biotechnology
    Volume20
    Issue number4
    Pages (from-to)191-195
    ISSN1464-1801
    DOIs
    Publication statusPublished - 2011

    Keywords

    • Pleiotropic drug resistance
    • PDR5
    • Lovastatin
    • Saccharomyces cerevisiae
    • Yeast

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