Abstract
Complex and miniaturized oral drug delivery systems are being developed rapidly for targeted, controlled drug release and improved bioavailability. Standard analytical techniques are widely used to characterize i) drug carrier and active pharmaceutical ingredients before loading into a delivery device (to ensure the solid form), and ii) the entire drug delivery system during the development process. However, in light of the complexity and the size of some of these systems, standard techniques as well as novel sensing technologies and experimental platforms need to be used in tandem. These technologies and platforms are discussed in this review, with a special focus on passive delivery systems in size range from a few 100 µm to a few mm. Challenges associated with characterizing these systems and evaluating their effect on oral drug delivery in the preclinical phase are also discussed.
| Original language | English |
|---|---|
| Article number | 113850 |
| Journal | Advanced Drug Delivery Reviews |
| Volume | 176 |
| Number of pages | 19 |
| ISSN | 0169-409X |
| DOIs | |
| Publication status | Published - 2021 |
Bibliographical note
Funding Information:All authors would like to acknowledge the Danish National Research Foundation (DNRF122) and Villum Fonden (Grant No. 9301) for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics (IDUN). STR, KZ, and AB acknowledged the financial support from BioInnovation Institute Foundation for Therapeutic drug monitoring (grant number NNF20SA0063552).
Keywords
- Active pharmaceutical ingredient
- Drug discovery
- Drug product
- In vitro systems
- Microdevices
- Microfabrication
- Oral drug delivery
- Solid-state
- Stability
- Standardization