TY - JOUR
T1 - Self-Healing Hydrogels: The Next Paradigm Shift in Tissue Engineering?
AU - Talebian, Sepehr
AU - Mehrali, Mehdi
AU - Taebnia, Nayere
AU - Pennisi, Cristian Pablo
AU - Kadumudi, Firoz Babu
AU - Foroughi, Javad
AU - Hasany, Masoud
AU - Nikkhah, Mehdi
AU - Akbari, Mohsen
AU - Orive, Gorka
AU - Dolatshahi-Pirouz, Alireza
PY - 2019
Y1 - 2019
N2 - Given their durability and long-term stability, self-healable hydrogels have, in the past few years, emerged as promising replacements for the many brittle hydrogels currently being used in preclinical or clinical trials. To this end, the incompatibility between hydrogel toughness and rapid self-healing remains unaddressed, and therefore most of the self-healable hydrogels still face serious challenges within the dynamic and mechanically demanding environment of human organs/tissues. Furthermore, depending on the target tissue, the self-healing hydrogels must comply with a wide range of properties including electrical, biological, and mechanical. Notably, the incorporation of nanomaterials into double-network hydrogels is showing great promise as a feasible way to generate self-healable hydrogels with the above-mentioned attributes. Here, the recent progress in the development of multifunctional and self-healable hydrogels for various tissue engineering applications is discussed in detail. Their potential applications within the rapidly expanding areas of bioelectronic hydrogels, cyborganics, and soft robotics are further highlighted.
AB - Given their durability and long-term stability, self-healable hydrogels have, in the past few years, emerged as promising replacements for the many brittle hydrogels currently being used in preclinical or clinical trials. To this end, the incompatibility between hydrogel toughness and rapid self-healing remains unaddressed, and therefore most of the self-healable hydrogels still face serious challenges within the dynamic and mechanically demanding environment of human organs/tissues. Furthermore, depending on the target tissue, the self-healing hydrogels must comply with a wide range of properties including electrical, biological, and mechanical. Notably, the incorporation of nanomaterials into double-network hydrogels is showing great promise as a feasible way to generate self-healable hydrogels with the above-mentioned attributes. Here, the recent progress in the development of multifunctional and self-healable hydrogels for various tissue engineering applications is discussed in detail. Their potential applications within the rapidly expanding areas of bioelectronic hydrogels, cyborganics, and soft robotics are further highlighted.
KW - Cyborganics
KW - Nanocomposite hydrogels
KW - Nanomaterials
KW - Self-healing hydrogels
KW - Tissue engineering
U2 - 10.1002/advs.201801664
DO - 10.1002/advs.201801664
M3 - Journal article
C2 - 31453048
SN - 2198-3844
VL - 6
JO - Advanced Science
JF - Advanced Science
IS - 16
M1 - 1801664
ER -