Self-assembly in nature: using the principles of nature to create complex nanobiomaterials

Ana Carina Loureiro Mendes, Erkan T. Baran, Rui L. Reis, Helena S. Azevedo

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Self-assembly is a ubiquitous process in biology where it plays numerous important roles and underlies the formation of a wide variety of complex biological structures. Over the past two decades, materials scientists have aspired to exploit nature's assembly principles to create artificial materials, with hierarchical structures and tailored properties, for the fabrication of functional devices. Toward this goal, both biological and synthetic building blocks have been subject of extensive research in self-assembly. In fact, molecular self-assembly is becoming increasingly important for the fabrication of biomaterials because it offers a great platform for constructing materials with high level of precision and complexity, integrating order and dynamics, to achieve functions such as stimuli-responsiveness, adaptation, recognition, transport, and catalysis. The importance of peptide self-assembling building blocks has been recognized in the last years, as demonstrated by the literature available on the topic. The simple structure of peptides, as well as their facile synthesis, makes peptides an excellent family of structural units for the bottom-up fabrication of complex nanobiomaterials. Additionally, peptides offer a great diversity of biochemical (specificity, intrinsic bioactivity, biodegradability) and physical (small size, conformation) properties to form self-assembled structures with different molecular configurations. The motivation of this review is to provide an overview on the design principles for peptide self-assembly and to illustrate how these principles have been applied to manipulate their self-assembly across the scales. Applications of self-assembling peptides as nanobiomaterials, including carriers for drug delivery, hydrogels for cell culture and tissue repair are also described. (C) 2013 Wiley Periodicals, Inc.
Original languageEnglish
JournalWiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
Volume5
Issue number6
Pages (from-to)582-612
Number of pages31
ISSN1939-0041
DOIs
Publication statusPublished - 2013
Externally publishedYes

Keywords

  • Animals
  • Biomedical Research
  • Biomimetic Materials
  • Biotechnology
  • Humans
  • Mice
  • Models, Biological
  • Nanostructures
  • Nanotechnology
  • Peptides
  • Protein Multimerization
  • Rats
  • NANOSCIENCE
  • MEDICINE,
  • PEPTIDE-AMPHIPHILE NANOFIBERS
  • TRANSMISSION ELECTRON-MICROSCOPY
  • SURFACTANT-LIKE PEPTIDES
  • COILED-COIL PEPTIDES
  • MARROW STROMAL CELLS
  • SPINAL-CORD-INJURY
  • BUILDING-BLOCKS
  • BONE REGENERATION
  • CONTROLLED-RELEASE
  • SUPRAMOLECULAR NANOSTRUCTURES
  • biodegradability
  • biomaterials
  • catalysis
  • hierarchical structures property
  • molecular configuration
  • nanobiomaterials
  • physical property
  • recognition
  • self-assembled structure
  • tailored property
  • hydrogels
  • peptides
  • 10064, Biochemistry studies - Proteins, peptides and amino acids
  • 10511, Biophysics - Bioengineering
  • 32500, Tissue culture, apparatus, methods and media
  • cell culture laboratory techniques, culturing techniques
  • drug delivery therapeutic and prophylactic techniques, clinical techniques
  • fabrication laboratory techniques
  • tissue repair mechanism laboratory techniques
  • Biomaterials
  • Biodegradation
  • Biological materials
  • Cell culture
  • Drug delivery
  • Fabrication
  • Self assembly
  • amphophile
  • nanomaterial
  • peptide derivative
  • self assembling peptide
  • unclassified drug
  • alpha helix
  • article
  • beta sheet
  • cartilage
  • cell culture
  • central nervous system
  • drug delivery system
  • hydrogel
  • hydrogen bond
  • hydrophobicity
  • microscopy
  • molecular interaction
  • nonhuman
  • priority journal
  • protein folding
  • protein secondary structure
  • regenerative medicine
  • revascularization
  • static electricity
  • supramolecular chemistry
  • tissue repair
  • Biological structures
  • Hierarchical structures
  • Molecular configurations
  • Molecular self assembly
  • Peptide self assemblies
  • Self assembled structures
  • Self-assembling peptides
  • Synthetic building blocks

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