Selenium: From fluorescent probes to biomedical application

Junping Wang, Mingkai Chen, Zhongyang Zhang, Li Ma*, Tianfeng Chen

*Corresponding author for this work

Research output: Contribution to journalReviewpeer-review

Abstract

Selenium (Se) is of fundamental importance to human health as an essential trace element, mainly through regulation of selenoproteins (SePs). Therefore, monitoring Se transformation in living systems and revealing cellular functions of SePs are of great significance for diverse disease treatment. However, the lack of probing tools for in situ monitoring of Se species severely hinders its development in bio-analysis. Thus, the discovery of fluorescent probes with specific recognition and responses to SePs/Se-containing species are promising for investigating the biological actions of Se. Herein, we summarized the chemical properties of various active Se species and discussed the rational design of basic structures of fluorescent probes for Se species and their biomedical applications. We also highlighted the key findings on fluorescent probes for Se species inside living systems, and proposed a network for rational design and biomedical applications of fluorescent probes for biological Se-containing substances.

Original languageEnglish
Article number215278
JournalCoordination Chemistry Reviews
Volume493
Number of pages23
ISSN0010-8545
DOIs
Publication statusPublished - 2023

Keywords

  • Biomedical application
  • Fluorescent probes
  • Selenium

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