Selective Serial Multi-Antibody Biosensing with TOPAS Microstructured Polymer Optical Fibers

Grigoriy Andreev Emiliyanov, Poul E. Høiby, Lars H. Pedersen, Ole Bang

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Abstract

We have developed a fluorescence-based fiber-optical biosensor, which can selectively detect different antibodies in serial at preselected positions inside a single piece of fiber. The fiber is a microstructured polymer optical fiber fabricated from TOPAS cyclic olefin copolymer, which allows for UV activation of localized sensor layers inside the holes of the fiber. Serial fluorescence-based selective sensing of Cy3-labelled α-streptavidin and Cy5-labelled α-CRP antibodies is demonstrated.
Original languageEnglish
JournalSensors
Volume13
Issue number3
Pages (from-to)3242-3251
ISSN1424-8220
DOIs
Publication statusPublished - 2013

Bibliographical note

© 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

Keywords

  • Microstructured polymer optical fiber
  • Fluorescence
  • Antibodies

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