Selective molecular adsorption using electrospun nanofiber membranes

K. Yoshimatsu, L. Ye, J. Lindberg, Ioannis S. Chronakis

Research output: Contribution to journalJournal articleResearchpeer-review


Molecularly imprinted nanoparticles were encapsulated into polymer nanofibers with a simple electrospinning method. The composite nanofibers form non-woven mats that can be used as affinity membrane to greatly simplify solid phase extraction of drug residues in analytical samples. Upward 100% of propranolol-imprinted nanoparticles can be easily encapsulated into poly(ethylene terephthalate) nanofibers, ensuring the composite materials to have a high specific binding capacity. As confirmed by radioligand binding analysis, the specific binding sites in the composite materials remain easily accessible and are chiral-selective. Using the new composite nanofiber mats as solid phase extraction materials, trace amount of propranolol (I ng mL(-1)) in tap water can be easily detected after a simple sample preparation. As validated in this study, there is no problem of template leakage from the composite nanofibers. Without the solid phase extraction, the existence of propranolol residues in water cannot be confirmed with even tandem HPLC-MS/MS analysis. (c) 2007 Elsevier B.V. All rights reserved.
Original languageEnglish
JournalBiosensors and Bioelectronics
Issue number7
Pages (from-to)1208-1215
Publication statusPublished - 2008
Externally publishedYes

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