Secondary metabolites characteristic of Penicillium citrinum,                Penicillium steckii and related species

J. Malmstrom; C. Christophersen; Jens Christian Frisvad

doi:10.1016/S0031-9422(00)00106-0

Secondary metabolites characteristic of Penicillium citrinum, Penicillium steckii and related species

J. Malmstrom, C. Christophersen, Jens Christian Frisvad

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Two new carboxylic acids, tanzawaic acid E (1) and F (2) in addition to the unknown benzopyran 3,7-dimethyl-1,8-dihydroxy6-methoxy-isochroman (3), and the known mycotoxin 3,7-dimethyl-8-hydroxy-6-methoxyisochroman (4) were produced by a marine-derived strain of Penicillium steckii isolated from an unidentified tunicate. The carboxylic acids and the benzopyran were identified on the basis of mass spectrometry, and one and two dimensional NMR spectroscopic techniques. The structures 1 and 2 resemble tanzawaic acid A-D, previously isolated from Penicillium citrinum. Screening of isolates of species related to P. citrinum and P. steckii showed that P. citrinum (25 isolates) consistently produced citrinin and tanzawaic acid A. P. steckii (18 isolates) produced isochroman toxins (except 2) and tanzawaic acid E. P. sizovae consistently produced tanzawaic acid A. P. corylophilum (10 isolates) produced citreoisocoumarinol and P. sumatrense (15 isolates) always produced curvularin. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original language	English
Journal	Phytochemistry
Volume	54
Issue number	3
Pages (from-to)	301-309
ISSN	0031-9422
DOIs	https://doi.org/10.1016/S0031-9422(00)00106-0
Publication status	Published - 2000

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S0031-9422(00)00106-0

OpenUrl availability

Full text

Cite this

@article{63651dc95ad8442da397da00e59d34e4,

title = "Secondary metabolites characteristic of Penicillium citrinum, Penicillium steckii and related species",

abstract = "Two new carboxylic acids, tanzawaic acid E (1) and F (2) in addition to the unknown benzopyran 3,7-dimethyl-1,8-dihydroxy6-methoxy-isochroman (3), and the known mycotoxin 3,7-dimethyl-8-hydroxy-6-methoxyisochroman (4) were produced by a marine-derived strain of Penicillium steckii isolated from an unidentified tunicate. The carboxylic acids and the benzopyran were identified on the basis of mass spectrometry, and one and two dimensional NMR spectroscopic techniques. The structures 1 and 2 resemble tanzawaic acid A-D, previously isolated from Penicillium citrinum. Screening of isolates of species related to P. citrinum and P. steckii showed that P. citrinum (25 isolates) consistently produced citrinin and tanzawaic acid A. P. steckii (18 isolates) produced isochroman toxins (except 2) and tanzawaic acid E. P. sizovae consistently produced tanzawaic acid A. P. corylophilum (10 isolates) produced citreoisocoumarinol and P. sumatrense (15 isolates) always produced curvularin. (C) 2000 Elsevier Science Ltd. All rights reserved. ",

author = "J. Malmstrom and C. Christophersen and Frisvad, {Jens Christian}",

year = "2000",

doi = "10.1016/S0031-9422(00)00106-0",

language = "English",

volume = "54",

pages = "301--309",

journal = "Phytochemistry",

issn = "0031-9422",

publisher = "Pergamon Press",

number = "3",

}

TY - JOUR

T1 - Secondary metabolites characteristic of Penicillium citrinum, Penicillium steckii and related species

AU - Malmstrom, J.

AU - Christophersen, C.

AU - Frisvad, Jens Christian

PY - 2000

Y1 - 2000

N2 - Two new carboxylic acids, tanzawaic acid E (1) and F (2) in addition to the unknown benzopyran 3,7-dimethyl-1,8-dihydroxy6-methoxy-isochroman (3), and the known mycotoxin 3,7-dimethyl-8-hydroxy-6-methoxyisochroman (4) were produced by a marine-derived strain of Penicillium steckii isolated from an unidentified tunicate. The carboxylic acids and the benzopyran were identified on the basis of mass spectrometry, and one and two dimensional NMR spectroscopic techniques. The structures 1 and 2 resemble tanzawaic acid A-D, previously isolated from Penicillium citrinum. Screening of isolates of species related to P. citrinum and P. steckii showed that P. citrinum (25 isolates) consistently produced citrinin and tanzawaic acid A. P. steckii (18 isolates) produced isochroman toxins (except 2) and tanzawaic acid E. P. sizovae consistently produced tanzawaic acid A. P. corylophilum (10 isolates) produced citreoisocoumarinol and P. sumatrense (15 isolates) always produced curvularin. (C) 2000 Elsevier Science Ltd. All rights reserved.

AB - Two new carboxylic acids, tanzawaic acid E (1) and F (2) in addition to the unknown benzopyran 3,7-dimethyl-1,8-dihydroxy6-methoxy-isochroman (3), and the known mycotoxin 3,7-dimethyl-8-hydroxy-6-methoxyisochroman (4) were produced by a marine-derived strain of Penicillium steckii isolated from an unidentified tunicate. The carboxylic acids and the benzopyran were identified on the basis of mass spectrometry, and one and two dimensional NMR spectroscopic techniques. The structures 1 and 2 resemble tanzawaic acid A-D, previously isolated from Penicillium citrinum. Screening of isolates of species related to P. citrinum and P. steckii showed that P. citrinum (25 isolates) consistently produced citrinin and tanzawaic acid A. P. steckii (18 isolates) produced isochroman toxins (except 2) and tanzawaic acid E. P. sizovae consistently produced tanzawaic acid A. P. corylophilum (10 isolates) produced citreoisocoumarinol and P. sumatrense (15 isolates) always produced curvularin. (C) 2000 Elsevier Science Ltd. All rights reserved.

U2 - 10.1016/S0031-9422(00)00106-0

DO - 10.1016/S0031-9422(00)00106-0

M3 - Journal article

SN - 0031-9422

VL - 54

SP - 301

EP - 309

JO - Phytochemistry

JF - Phytochemistry

IS - 3

ER -