Secondary immune response of rainbow trout following repeated immersion vaccination

R. M. Jaafar*, Azmi Al-Jubury, Jiwan Kumar Chettri, Inger Dalsgaard, P. W. Kania, K. Buchmann

*Corresponding author for this work

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Teleosts are able to raise a protective immune response, comprising both innate and adaptive elements, against various pathogens. This is the basis for a widespread use of vaccines, administered as injection or immersion, in the aquaculture industry. It has been described that repeated injection vaccination of fish raises a secondary immune response, consisting of rapid, accelerated and increased antibody reaction. This study reports how rainbow trout responds to repeated immersion vaccination against yersiniosis (ERM) caused by the bacterial pathogen Yersinia ruckeri. It was found that rainbow trout does not raise a classical secondary response following repeated immersion vaccination. Serum antibody titres were merely slightly increased even after three immunizations, using 30-s immersion into a bacterin consisting of formalin-inactivated Y. ruckeri (serotype O1, biotypes 1 and 2), performed over a 3-month period. The densities of IgM-positive lymphocytes in spleen of fish immunized three times were increased compared to control fish, but no general trend for an increase with the number of immunizations was noted. The lack of a classical secondary response following repeated immersion vaccination may partly be explained by limited uptake of antigen by immersion compared to injection.
    Original languageEnglish
    JournalJournal of Fish Diseases
    Volume41
    Issue number1
    Pages (from-to)117-123
    ISSN0140-7775
    DOIs
    Publication statusPublished - 2018

    Keywords

    • Yersinia ruckeri
    • IgM
    • immersion
    • vaccination

    Cite this

    Jaafar, R. M. ; Al-Jubury, Azmi ; Chettri, Jiwan Kumar ; Dalsgaard, Inger ; Kania, P. W. ; Buchmann, K. / Secondary immune response of rainbow trout following repeated immersion vaccination. In: Journal of Fish Diseases. 2018 ; Vol. 41, No. 1. pp. 117-123.
    @article{f67bf12cdc8540d1b8d6558d9a85ba66,
    title = "Secondary immune response of rainbow trout following repeated immersion vaccination",
    abstract = "Teleosts are able to raise a protective immune response, comprising both innate and adaptive elements, against various pathogens. This is the basis for a widespread use of vaccines, administered as injection or immersion, in the aquaculture industry. It has been described that repeated injection vaccination of fish raises a secondary immune response, consisting of rapid, accelerated and increased antibody reaction. This study reports how rainbow trout responds to repeated immersion vaccination against yersiniosis (ERM) caused by the bacterial pathogen Yersinia ruckeri. It was found that rainbow trout does not raise a classical secondary response following repeated immersion vaccination. Serum antibody titres were merely slightly increased even after three immunizations, using 30-s immersion into a bacterin consisting of formalin-inactivated Y. ruckeri (serotype O1, biotypes 1 and 2), performed over a 3-month period. The densities of IgM-positive lymphocytes in spleen of fish immunized three times were increased compared to control fish, but no general trend for an increase with the number of immunizations was noted. The lack of a classical secondary response following repeated immersion vaccination may partly be explained by limited uptake of antigen by immersion compared to injection.",
    keywords = "Yersinia ruckeri, IgM, immersion, vaccination",
    author = "Jaafar, {R. M.} and Azmi Al-Jubury and Chettri, {Jiwan Kumar} and Inger Dalsgaard and Kania, {P. W.} and K. Buchmann",
    year = "2018",
    doi = "10.1111/jfd.12682",
    language = "English",
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    pages = "117--123",
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    Jaafar, RM, Al-Jubury, A, Chettri, JK, Dalsgaard, I, Kania, PW & Buchmann, K 2018, 'Secondary immune response of rainbow trout following repeated immersion vaccination', Journal of Fish Diseases, vol. 41, no. 1, pp. 117-123. https://doi.org/10.1111/jfd.12682

    Secondary immune response of rainbow trout following repeated immersion vaccination. / Jaafar, R. M.; Al-Jubury, Azmi; Chettri, Jiwan Kumar; Dalsgaard, Inger; Kania, P. W.; Buchmann, K.

    In: Journal of Fish Diseases, Vol. 41, No. 1, 2018, p. 117-123.

    Research output: Contribution to journalJournal articleResearchpeer-review

    TY - JOUR

    T1 - Secondary immune response of rainbow trout following repeated immersion vaccination

    AU - Jaafar, R. M.

    AU - Al-Jubury, Azmi

    AU - Chettri, Jiwan Kumar

    AU - Dalsgaard, Inger

    AU - Kania, P. W.

    AU - Buchmann, K.

    PY - 2018

    Y1 - 2018

    N2 - Teleosts are able to raise a protective immune response, comprising both innate and adaptive elements, against various pathogens. This is the basis for a widespread use of vaccines, administered as injection or immersion, in the aquaculture industry. It has been described that repeated injection vaccination of fish raises a secondary immune response, consisting of rapid, accelerated and increased antibody reaction. This study reports how rainbow trout responds to repeated immersion vaccination against yersiniosis (ERM) caused by the bacterial pathogen Yersinia ruckeri. It was found that rainbow trout does not raise a classical secondary response following repeated immersion vaccination. Serum antibody titres were merely slightly increased even after three immunizations, using 30-s immersion into a bacterin consisting of formalin-inactivated Y. ruckeri (serotype O1, biotypes 1 and 2), performed over a 3-month period. The densities of IgM-positive lymphocytes in spleen of fish immunized three times were increased compared to control fish, but no general trend for an increase with the number of immunizations was noted. The lack of a classical secondary response following repeated immersion vaccination may partly be explained by limited uptake of antigen by immersion compared to injection.

    AB - Teleosts are able to raise a protective immune response, comprising both innate and adaptive elements, against various pathogens. This is the basis for a widespread use of vaccines, administered as injection or immersion, in the aquaculture industry. It has been described that repeated injection vaccination of fish raises a secondary immune response, consisting of rapid, accelerated and increased antibody reaction. This study reports how rainbow trout responds to repeated immersion vaccination against yersiniosis (ERM) caused by the bacterial pathogen Yersinia ruckeri. It was found that rainbow trout does not raise a classical secondary response following repeated immersion vaccination. Serum antibody titres were merely slightly increased even after three immunizations, using 30-s immersion into a bacterin consisting of formalin-inactivated Y. ruckeri (serotype O1, biotypes 1 and 2), performed over a 3-month period. The densities of IgM-positive lymphocytes in spleen of fish immunized three times were increased compared to control fish, but no general trend for an increase with the number of immunizations was noted. The lack of a classical secondary response following repeated immersion vaccination may partly be explained by limited uptake of antigen by immersion compared to injection.

    KW - Yersinia ruckeri

    KW - IgM

    KW - immersion

    KW - vaccination

    U2 - 10.1111/jfd.12682

    DO - 10.1111/jfd.12682

    M3 - Journal article

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