Screening Platform for Identification of Suitable Monomer Mixtures Able To Form Thin-Film Coatings on Polyurethanes by UV-Initiated Free Radical Polymerization

Christian Andersen, Niels Jørgen Madsen, Anders E. Daugaard*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Screening platforms have become a valuable tool for exploring large libraries of surface chemistries helping the discovery of new materials for especially biological applications. Methods applied in these platforms, however, are mainly based on inert bulk synthesis at picoliter scale, resulting in noncovalently attached molecules on stiff glass substrates. This is a poor representation of a potential final product from an industrial perspective. To overcome this, we have developed a screening platform capable of conducting UV-initiated free radical polymerization (FRP) directly onto a flexible polyurethane under ambient conditions. The platform allows for the study of solvent and monomer effects under industrially relevant conditions and was used to graft a series of homo- and copolymer systems (2,2,2-trifluoroethyl methacrylate (TrFEMA), N-isopropylacrylamide (NIPAAm), diethylene glycol methyl ether methacrylate-co-poly(ethylene glycol) methyl ether methacrylate, (MDEGMA-co-MPEGMA), and acrylic acid (AA)), which was confirmed by both water contact angle (WCA) and X-ray photoelectron spectroscopy (XPS) analysis. The versatility of the system was further demonstrated through investigation of terpolymer systems and direct evaluation of their antifouling properties using a fluorescein-labeled bovine serum albumin (BSA).
Original languageEnglish
JournalAcs Applied Polymer Materials
Volume1
Issue number12
Pages (from-to)3295-3303
ISSN2637-6105
DOIs
Publication statusPublished - 2019

Keywords

  • Monomers
  • Organic polymers
  • Organic compounds
  • X-ray photoelectron spectroscopy
  • Polymers

Cite this

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title = "Screening Platform for Identification of Suitable Monomer Mixtures Able To Form Thin-Film Coatings on Polyurethanes by UV-Initiated Free Radical Polymerization",
abstract = "Screening platforms have become a valuable tool for exploring large libraries of surface chemistries helping the discovery of new materials for especially biological applications. Methods applied in these platforms, however, are mainly based on inert bulk synthesis at picoliter scale, resulting in noncovalently attached molecules on stiff glass substrates. This is a poor representation of a potential final product from an industrial perspective. To overcome this, we have developed a screening platform capable of conducting UV-initiated free radical polymerization (FRP) directly onto a flexible polyurethane under ambient conditions. The platform allows for the study of solvent and monomer effects under industrially relevant conditions and was used to graft a series of homo- and copolymer systems (2,2,2-trifluoroethyl methacrylate (TrFEMA), N-isopropylacrylamide (NIPAAm), diethylene glycol methyl ether methacrylate-co-poly(ethylene glycol) methyl ether methacrylate, (MDEGMA-co-MPEGMA), and acrylic acid (AA)), which was confirmed by both water contact angle (WCA) and X-ray photoelectron spectroscopy (XPS) analysis. The versatility of the system was further demonstrated through investigation of terpolymer systems and direct evaluation of their antifouling properties using a fluorescein-labeled bovine serum albumin (BSA).",
keywords = "Monomers, Organic polymers, Organic compounds, X-ray photoelectron spectroscopy, Polymers",
author = "Christian Andersen and Madsen, {Niels J{\o}rgen} and Daugaard, {Anders E.}",
year = "2019",
doi = "10.1021/acsapm.9b00744",
language = "English",
volume = "1",
pages = "3295--3303",
journal = "Acs Applied Polymer Materials",
issn = "2637-6105",
publisher = "American Chemical Society",
number = "12",

}

Screening Platform for Identification of Suitable Monomer Mixtures Able To Form Thin-Film Coatings on Polyurethanes by UV-Initiated Free Radical Polymerization. / Andersen, Christian; Madsen, Niels Jørgen; Daugaard, Anders E.

In: Acs Applied Polymer Materials, Vol. 1, No. 12, 2019, p. 3295-3303.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Screening Platform for Identification of Suitable Monomer Mixtures Able To Form Thin-Film Coatings on Polyurethanes by UV-Initiated Free Radical Polymerization

AU - Andersen, Christian

AU - Madsen, Niels Jørgen

AU - Daugaard, Anders E.

PY - 2019

Y1 - 2019

N2 - Screening platforms have become a valuable tool for exploring large libraries of surface chemistries helping the discovery of new materials for especially biological applications. Methods applied in these platforms, however, are mainly based on inert bulk synthesis at picoliter scale, resulting in noncovalently attached molecules on stiff glass substrates. This is a poor representation of a potential final product from an industrial perspective. To overcome this, we have developed a screening platform capable of conducting UV-initiated free radical polymerization (FRP) directly onto a flexible polyurethane under ambient conditions. The platform allows for the study of solvent and monomer effects under industrially relevant conditions and was used to graft a series of homo- and copolymer systems (2,2,2-trifluoroethyl methacrylate (TrFEMA), N-isopropylacrylamide (NIPAAm), diethylene glycol methyl ether methacrylate-co-poly(ethylene glycol) methyl ether methacrylate, (MDEGMA-co-MPEGMA), and acrylic acid (AA)), which was confirmed by both water contact angle (WCA) and X-ray photoelectron spectroscopy (XPS) analysis. The versatility of the system was further demonstrated through investigation of terpolymer systems and direct evaluation of their antifouling properties using a fluorescein-labeled bovine serum albumin (BSA).

AB - Screening platforms have become a valuable tool for exploring large libraries of surface chemistries helping the discovery of new materials for especially biological applications. Methods applied in these platforms, however, are mainly based on inert bulk synthesis at picoliter scale, resulting in noncovalently attached molecules on stiff glass substrates. This is a poor representation of a potential final product from an industrial perspective. To overcome this, we have developed a screening platform capable of conducting UV-initiated free radical polymerization (FRP) directly onto a flexible polyurethane under ambient conditions. The platform allows for the study of solvent and monomer effects under industrially relevant conditions and was used to graft a series of homo- and copolymer systems (2,2,2-trifluoroethyl methacrylate (TrFEMA), N-isopropylacrylamide (NIPAAm), diethylene glycol methyl ether methacrylate-co-poly(ethylene glycol) methyl ether methacrylate, (MDEGMA-co-MPEGMA), and acrylic acid (AA)), which was confirmed by both water contact angle (WCA) and X-ray photoelectron spectroscopy (XPS) analysis. The versatility of the system was further demonstrated through investigation of terpolymer systems and direct evaluation of their antifouling properties using a fluorescein-labeled bovine serum albumin (BSA).

KW - Monomers

KW - Organic polymers

KW - Organic compounds

KW - X-ray photoelectron spectroscopy

KW - Polymers

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DO - 10.1021/acsapm.9b00744

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JO - Acs Applied Polymer Materials

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SN - 2637-6105

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