TY - JOUR
T1 - Screening of organic solvents for bioprocesses using aqueous-organic two-phase systems
AU - Rosinha Grundtvig, Inês P.
AU - Heintz, Søren
AU - Krühne, Ulrich
AU - Gernaey, Krist V.
AU - Adlercreutz, Patrick
AU - Hayler, John D.
AU - Wells, Andy S.
AU - Woodley, John M.
PY - 2018
Y1 - 2018
N2 - The application of conventional organic solvents has been essential in several steps of bioprocesses in order to achieve sufficient economic efficiency. The use of organic solvents is frequently essential either to partly or fully replace water in the reaction medium or as a process aid for downstream separation. Nowadays, manufacturers are increasingly requested to avoid and substitute solvents with hazardous potential. Therefore, the solvent selection must account for potential environmental hazards, health and safety problems, in addition to fulfilling the ideal characteristics for application in a process. For the first time, criteria including Environment, Health and Safety (EHS), as well as the technical requirements for reaction and separation have been reviewed, collected and integrated in a single screening strategy to be used as a guideline for narrowing down the list of solvents to test experimentally. Additionally, we have also included a solvent selection guide based on the methodology developed in the Innovative Medicines Initiative CHEM21 (IMI CHEM21) project and applied specifically to water-immiscible solvents commonly used in bioprocesses.
AB - The application of conventional organic solvents has been essential in several steps of bioprocesses in order to achieve sufficient economic efficiency. The use of organic solvents is frequently essential either to partly or fully replace water in the reaction medium or as a process aid for downstream separation. Nowadays, manufacturers are increasingly requested to avoid and substitute solvents with hazardous potential. Therefore, the solvent selection must account for potential environmental hazards, health and safety problems, in addition to fulfilling the ideal characteristics for application in a process. For the first time, criteria including Environment, Health and Safety (EHS), as well as the technical requirements for reaction and separation have been reviewed, collected and integrated in a single screening strategy to be used as a guideline for narrowing down the list of solvents to test experimentally. Additionally, we have also included a solvent selection guide based on the methodology developed in the Innovative Medicines Initiative CHEM21 (IMI CHEM21) project and applied specifically to water-immiscible solvents commonly used in bioprocesses.
KW - Bioprocesses
KW - Biphasic systems
KW - Downstream processing
KW - In situ product removal
KW - Organic solvents screening
U2 - 10.1016/j.biotechadv.2018.05.007
DO - 10.1016/j.biotechadv.2018.05.007
M3 - Journal article
C2 - 29864458
SN - 0734-9750
VL - 36
SP - 1801
EP - 1814
JO - Biotechnology Advances
JF - Biotechnology Advances
IS - 7
ER -