Fungi are a valuable source of metabolites and other bioactive compounds. These compounds are essential for human society, and it is estimated that around 49% of the drugs used to treat cancer are natural products or derived therefrom. Six different wild types of Aspergillus nidulans have been cultured on a range of different habitat mimicking media. Extracts from the fungi were analyzed using a LC-DAD-TOFMS system, and by screening the extracts using an in-house database of known fungal metabolites. Using this database we were able to easily select unknown compounds, and dereplicate these using the spectrometric and spectroscopic data obtained from the analysis. The Analysis revealed several metabolites not previously reported in A. nidulans as well as a novel metabolite.
|Publication status||Published - 2012|
|Event||International Congress on Natural Products Research on Global Change, Natural Products and Human Health: 8th Joint Meeting of AFERP, ASP, GA, PSE and SIF - New York City, NY, United States|
Duration: 28 Jul 2012 → 1 Aug 2012
|Conference||International Congress on Natural Products Research on Global Change, Natural Products and Human Health|
|City||New York City, NY|
|Period||28/07/2012 → 01/08/2012|