Screening of Aspergillus nidulans metabolites from habitat mimicking media using LC-DAD-TOFMS system

Andreas Klitgaard, Dorte Koefoed Holm, Jens Christian Frisvad, Kristian Fog Nielsen

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

    Abstract

    Fungi are a valuable source of metabolites and other bioactive compounds. These compounds are essential for human society, and it is estimated that around 49% of the drugs used to treat cancer are natural products or derived therefrom. Six different wild types of Aspergillus nidulans have been cultured on a range of different habitat mimicking media. Extracts from the fungi were analyzed using a LC-DAD-TOFMS system, and by screening the extracts using an in-house database of known fungal metabolites. Using this database we were able to easily select unknown compounds, and dereplicate these using the spectrometric and spectroscopic data obtained from the analysis. The Analysis revealed several metabolites not previously reported in A. nidulans as well as a novel metabolite.
    Original languageEnglish
    JournalPlanta Medica
    Volume78
    Issue numberP167
    ISSN0032-0943
    DOIs
    Publication statusPublished - 2012
    EventInternational Congress on Natural Products Research on Global Change, Natural Products and Human Health: 8th Joint Meeting of AFERP, ASP, GA, PSE and SIF - New York City, NY, United States
    Duration: 28 Jul 20121 Aug 2012

    Conference

    ConferenceInternational Congress on Natural Products Research on Global Change, Natural Products and Human Health
    CountryUnited States
    CityNew York City, NY
    Period28/07/201201/08/2012

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