Scientific principles for the identification of endocrine-disrupting chemicals: a consensus statement

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  • Author: Solecki, Roland

    Federal Institute for Risk Assessment, Germany

  • Author: Kortenkamp, Andreas

    Brunel University, United Kingdom

  • Author: Bergman, Åke

    Swedish Toxicology Sciences Research Center (Swetox), Sweden

  • Author: Chahoud, Ibrahim

    Charité – Universitätsmedizin Berlin, Germany

  • Author: Degen, Gisela H

    Leibniz Research Centre for Working Environment and Human Factors, Germany

  • Author: Dietrich, Daniel

    Universität Konstanz, Germany

  • Author: Greim, Helmut

    Technische Universität München, Germany

  • Author: Håkansson, Helen

    Karolinska Institutet, Sweden

  • Author: Hass, Ulla

    Research Group for Reproductive Toxicology, National Food Institute, Technical University of Denmark, Kemitorvet, 2800, Kgs. Lyngby, Denmark

  • Author: Husoy, Trine

    Norwegian Institute of Public Health, Norway

  • Author: Jacobs, Miriam

    Public Health England, United Kingdom

  • Author: Jobling, Susan

    Brunel University, United Kingdom

  • Author: Mantovani, Alberto

    Istituto Superiore di Sanita, Italy

  • Author: Marx-Stoelting, Philip

    Federal Institute for Risk Assessment, Germany

  • Author: Piersma, Aldert H.

    National Institute of Public Health and the Environment, Netherlands

  • Author: Ritz, Vera

    Federal Institute for Risk Assessment, Germany

  • Author: Slama, Rémy

    Institut National de la Santé et de la Recherche Médicale, France

  • Author: Stahlmann, Ralf

    Charité – Universitätsmedizin Berlin, Germany

  • Author: van den Berg, Martin

    Utrecht University, Netherlands

  • Author: Zoeller, R. Thomas

    University of Massachusetts, United States

  • Author: Boobis, Alan R.

    Imperial College London, United Kingdom

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Endocrine disruption is a specific form of toxicity, where natural and/or anthropogenic chemicals, known as "endocrine disruptors" (EDs), trigger adverse health effects by disrupting the endogenous hormone system. There is need to harmonize guidance on the regulation of EDs, but this has been hampered by what appeared as a lack of consensus among scientists. This publication provides summary information about a consensus reached by a group of world-leading scientists that can serve as the basis for the development of ED criteria in relevant EU legislation. Twenty-three international scientists from different disciplines discussed principles and open questions on ED identification as outlined in a draft consensus paper at an expert meeting hosted by the German Federal Institute for Risk Assessment (BfR) in Berlin, Germany on 11-12 April 2016. Participants reached a consensus regarding scientific principles for the identification of EDs. The paper discusses the consensus reached on background, definition of an ED and related concepts, sources of uncertainty, scientific principles important for ED identification, and research needs. It highlights the difficulty in retrospectively reconstructing ED exposure, insufficient range of validated test systems for EDs, and some issues impacting on the evaluation of the risk from EDs, such as non-monotonic dose-response and thresholds, modes of action, and exposure assessment. This report provides the consensus statement on EDs agreed among all participating scientists. The meeting facilitated a productive debate and reduced a number of differences in views. It is expected that the consensus reached will serve as an important basis for the development of regulatory ED criteria.
Original languageEnglish
JournalArchives of Toxicology
Volume91
Issue number2
Pages (from-to)1001-1006
Number of pages6
ISSN0340-5761
DOIs
Publication statusPublished - 2017

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© The Author(s) 2016. This article is published with open access at Springerlink.com

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