Scientific Opinion on Flavouring Group Evaluation 210 Revision 2 (FGE.210Rev2): Consideration of genotoxic potential for α,β-unsaturated alicyclic ketones and precursors from chemical subgroup 2.4 of FGE.19

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Abstract

Safety Authority was requested to evaluate the genotoxic potential of 14 flavouring substances in Flavouring Group Evaluation 210 (FGE.210). In FGE.210, the Panel concluded that the genotoxic potential could not be ruled out for any of the flavouring substances. In FGE.210 Revision1, the Panel concluded that the concern for genotoxic potential is ruled out for eight substances [FL-no: 02.105, 07.007, 07.009, 07.011, 07.036, 07.088, 07.091 and 07.170] while for allyl a-ionone [FL-no: 07.061], for a-damascone [FL-no: 07.134] and four structurally related substances [FL-no: 07.130, 07.225, 07.226 and 07.231] the concern for genotoxicity remains and additional data were requested. The Flavour Industry has submitted additional genotoxicity data for allyl a-ionone [FL-no: 07.061], that are evaluated in the present revision of FGE.210 (Revision 2). Based on these new data the Panel concluded that the genotoxicity concern for allyl a-ionone [FL-no: 07.061] can be ruled out. For a-damascone [FL-no: 07.134] and the four structurally related substances [FL-no: 07.130, 07.225, 07.226 and 07.231] additional genotoxicity data are still required.
Original languageEnglish
Place of PublicationParma, Italy
PublisherEuropen Food Safety Authority
Number of pages33
DOIs
Publication statusPublished - 2015
Seriesthe EFSA Journal
Number4172
Volume13(7)
ISSN1830-5458

Keywords

  • α,β/unsaturated alicyclic ketones
  • flavouring subs tances
  • Safety evaluation

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