Scanning conductance microscopy investigations on fixed human chromosomes

Casper Hyttel Clausen; Jacob Moresco Lange; Linda Boye Jensen; Pranjul Jaykumar Shah; M. I. Dimaki; Winnie Edith Svendsen

doi:10.2144/000112676

Scanning conductance microscopy investigations on fixed human chromosomes

Casper Hyttel Clausen, Jacob Moresco Lange, Linda Boye Jensen, Pranjul Jaykumar Shah, M. I. Dimaki, Winnie Edith Svendsen

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Scanning conductance microscopy investigations were carried out in air on human chromosomes fixed on pre-fabricated SiO2 surfaces with a backgate. The point of the investigation was to estimate the dielectric constant of fixed human chromosomes in order to use it for microfluidic device optimization. The phase shift caused by the electrostatic forces, together with geometrical measurements of the atomic force microscopy (AFM) cantilever and the chromosomes were used to estimate a value,for the dielectric constant of different human chromosomes.

Original language	English
Journal	BioTechniques
Volume	44
Issue number	2
Pages (from-to)	225-228
ISSN	0736-6205
DOIs	https://doi.org/10.2144/000112676
Publication status	Published - 2008

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title = "Scanning conductance microscopy investigations on fixed human chromosomes",

abstract = "Scanning conductance microscopy investigations were carried out in air on human chromosomes fixed on pre-fabricated SiO2 surfaces with a backgate. The point of the investigation was to estimate the dielectric constant of fixed human chromosomes in order to use it for microfluidic device optimization. The phase shift caused by the electrostatic forces, together with geometrical measurements of the atomic force microscopy (AFM) cantilever and the chromosomes were used to estimate a value,for the dielectric constant of different human chromosomes.",

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AU - Clausen, Casper Hyttel

AU - Lange, Jacob Moresco

AU - Jensen, Linda Boye

AU - Shah, Pranjul Jaykumar

AU - Dimaki, M. I.

AU - Svendsen, Winnie Edith

PY - 2008

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N2 - Scanning conductance microscopy investigations were carried out in air on human chromosomes fixed on pre-fabricated SiO2 surfaces with a backgate. The point of the investigation was to estimate the dielectric constant of fixed human chromosomes in order to use it for microfluidic device optimization. The phase shift caused by the electrostatic forces, together with geometrical measurements of the atomic force microscopy (AFM) cantilever and the chromosomes were used to estimate a value,for the dielectric constant of different human chromosomes.

AB - Scanning conductance microscopy investigations were carried out in air on human chromosomes fixed on pre-fabricated SiO2 surfaces with a backgate. The point of the investigation was to estimate the dielectric constant of fixed human chromosomes in order to use it for microfluidic device optimization. The phase shift caused by the electrostatic forces, together with geometrical measurements of the atomic force microscopy (AFM) cantilever and the chromosomes were used to estimate a value,for the dielectric constant of different human chromosomes.

U2 - 10.2144/000112676

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SN - 0736-6205

VL - 44

SP - 225

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JO - BioTechniques

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ER -

Scanning conductance microscopy investigations on fixed human chromosomes

Abstract

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