Scale-up Modeling of a Pharmaceutical Crystallization Process via Compartmentalization Approach

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedings – Annual report year: 2019Researchpeer-review

View graph of relations

In this work, a scale-up model of a pharmaceutical batch cooling crystallization process was developed. The model is based on a compartmentalization approach of a large-scale crystallizer. The compartmental properties (e.g. volume, location and flux connections) were extracted by using two different, manual and automatic zoning, strategies. Each compartmentalization technique is based on a mixing study in the large-scale reactor with the help of computational fluid dynamics (CFD). The scale-up model was simulated in MATLAB/Simulink environment. The simulation results show the significant role of the fluid dynamics on the simulated process performance in terms of crystal size distribution and final average crystal diameter by means of comparing the multi-compartment model with a single-compartment well-mixed model.

Original languageEnglish
Title of host publicationProceedings of the 13th International Symposium on Process Systems Engineering – PSE 2018
EditorsMario R. Eden, Marianthi G. Ierapetritou, Gavin P. Towler
Publication date2018
ISBN (Electronic)978-0-444-64241-7
Publication statusPublished - 2018
Event13th International Symposium on Process Systems Engineering (PSE 2018) - San DIego, United States
Duration: 1 Jul 20185 Jul 2018


Conference13th International Symposium on Process Systems Engineering (PSE 2018)
CountryUnited States
CitySan DIego
SeriesComputer Aided Chemical Engineering
CitationsWeb of Science® Times Cited: No match on DOI

    Research areas

  • Scale-up modeling, Pharmaceutical crystallization, Compartmental modelling, Computational fluid dynamics

ID: 183856342