Scaffold Diversity from N-Acyliminium Ions

Peng Wu, Thomas E Nielsen

Research output: Contribution to journalJournal articleResearchpeer-review


N-Acyliminium ions are powerful reactive species for the formation of carbon-carbon and carbon-heteroatom bonds. Strategies relying on intramolecular reactions of N-acyliminium intermediates, also referred to as N-acyliminium ion cyclization reactions, have been employed for the construction of structurally diverse scaffolds, ranging from simple bicyclic skeletons to complex polycyclic systems and natural-product-like compounds. This review aims to provide an overview of cyclization reactions of N-acyliminium ions derived from various precursors for the assembly of structurally diverse scaffolds, covering the literature over the past 12 years (from 2004 to 2015).
Original languageEnglish
JournalChemical Reviews
Issue number12
Pages (from-to)7811-7856
Number of pages46
Publication statusPublished - 2017

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