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SBMLtoOdin and Menelmacar: interactive visualisation of systems biology models for expert and non-expert audiences

  • Leonie J. Lorenz
  • , Antoine Andréoletti
  • , Tung V.N. Nguyen
  • , Henning Hermjakob
  • , Richard G. FitzJohn
  • , Rahuman S. Malik Sheriff
  • , John A. Lees*
  • *Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Computational models in biology can increase our understanding of biological systems, be used to answer research questions, and make predictions. Accessibility and reusability of computational models is limited and often restricted to experts in programming and mathematics. This is due to the need to implement entire models and solvers from the mathematical notation models are normally presented as. Here, we present SBMLtoOdin, an R package that translates differential equation models in SBML format from the BioModels database into executable R code using the R package odin, allowing researchers to easily reuse models. We also present Menelmacar, a web-based application that provides interactive visualisations of these models by solving their differential equations in the browser. This platform allows non-experts to simulate and investigate models using an easy-to-use interface.

Original languageEnglish
Article numberbtaf484
JournalBioinformatics
Volume41
Issue number9
Number of pages5
ISSN1367-4803
DOIs
Publication statusPublished - 2025

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