Ruthenium-Catalyzed Alkylation of Oxindole with Alcohols

Thomas Jensen, Robert Madsen

Research output: Contribution to journalJournal articleResearchpeer-review


An atom-economical and solvent-free catalytic procedure for the mono-3-alkylation of oxindole with alcohols is described. The reaction is mediated by the in situ generated catalyst from RuCl3 center dot xH(2)O and PPh3 in the presence of sodium hydroxide, The reactions proceed in good to excellent yields with a wide range of aromatic, heteroaromatic, and aliphatic alcohols.
Original languageEnglish
JournalJournal of Organic Chemistry
Issue number10
Pages (from-to)3990-3992
Publication statusPublished - 2009


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