Role of Protein Phosphorylation in the Regulation of Cell Cycle and DNA-Related Processes in Bacteria

Transito Garcia-Garcia, Sandrine Poncet, Abderahmane Derouiche, Lei Shi, Ivan Mijakovic, Marie-Francoise Noirot-Gros

Research output: Contribution to journalJournal articleResearchpeer-review

370 Downloads (Pure)

Abstract

In all living organisms, the phosphorylation of proteins modulates various aspects of their functionalities. In eukaryotes, protein phosphorylation plays a key role in cell signaling, gene expression, and differentiation. Protein phosphorylation is also involved in the global control of DNA replication during the cell cycle, as well as in the mechanisms that cope with stress-induced replication blocks. Similar to eukaryotes, bacteria use Hanks-type kinases and phosphatases for signal transduction, and protein phosphorylation is involved in numerous cellular processes. However, it remains unclear whether protein phosphorylation in bacteria can also regulate the activity of proteins involved in DNA-mediated processes such as DNA replication or repair. Accumulating evidence supported by functional and biochemical studies suggests that phospho-regulatory mechanisms also take place during the bacterial cell cycle. Recent phosphoproteomics and interactomics studies identified numerous phosphoproteins involved in various aspect of DNA metabolism strongly supporting the existence of such level of regulation in bacteria. Similar to eukaryotes, bacterial scaffolding-like proteins emerged as platforms for kinase activation and signaling. This review reports the current knowledge on the phosphorylation of proteins involved in the maintenance of genome integrity and the regulation of cell cycle in bacteria that reveals surprising similarities to eukaryotes.
Original languageEnglish
Article number184
JournalFrontiers in Microbiology
Volume7
Number of pages11
ISSN1664-302X
DOIs
Publication statusPublished - 2016

Bibliographical note

© 2016 Garcia-Garcia, Poncet, Derouiche, Shi, Mijakovic and Noirot-Gros. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Keywords

  • DNA replication
  • Bacteria cell division
  • Bacterial cell cycle
  • Protein phosphorylation
  • Signaling

Fingerprint Dive into the research topics of 'Role of Protein Phosphorylation in the Regulation of Cell Cycle and DNA-Related Processes in Bacteria'. Together they form a unique fingerprint.

Cite this