Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19

Takuya Sekine; André Perez-Potti; Olga Rivera-Ballesteros; Kristoffer Strålin; Jean Baptiste Gorin; Annika Olsson; Sian Llewellyn-Lacey; Habiba Kamal; Gordana Bogdanovic; Sandra Muschiol; David J. Wullimann; Tobias Kammann; Johanna Emgård; Tiphaine Parrot; Elin Folkesson; Karolinska COVID-19 Study Group; Olav Rooyackers; Lars I. Eriksson; Jan Inge Henter; Anders Sönnerborg; Tobias Allander; Jan Albert; Morten Nielsen; Jonas Klingström; Sara Gredmark-Russ; Niklas K. Björkström; Johan K. Sandberg; David A. Price; Hans Gustaf Ljunggren; Soo Aleman; Marcus Buggert

doi:10.1016/j.cell.2020.08.017

Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19

Takuya Sekine, André Perez-Potti, Olga Rivera-Ballesteros, Kristoffer Strålin, Jean Baptiste Gorin, Annika Olsson, Sian Llewellyn-Lacey, Habiba Kamal, Gordana Bogdanovic, Sandra Muschiol, David J. Wullimann, Tobias Kammann, Johanna Emgård, Tiphaine Parrot, Elin Folkesson, Karolinska COVID-19 Study Group, Olav Rooyackers, Lars I. Eriksson, Jan Inge Henter, Anders SönnerborgTobias Allander, Jan Albert, Morten Nielsen, Jonas Klingström, Sara Gredmark-Russ, Niklas K. Björkström, Johan K. Sandberg, David A. Price, Hans Gustaf Ljunggren, Soo Aleman, Marcus Buggert

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. Here, we systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family members, and individuals with acute or convalescent COVID-19. Acute-phase SARS-CoV-2-specific T cells displayed a highly activated cytotoxic phenotype that correlated with various clinical markers of disease severity, whereas convalescent-phase SARS-CoV-2-specific T cells were polyfunctional and displayed a stem-like memory phenotype. Importantly, SARS-CoV-2-specific T cells were detectable in antibody-seronegative exposed family members and convalescent individuals with a history of asymptomatic and mild COVID-19. Our collective dataset shows that SARS-CoV-2 elicits broadly directed and functionally replete memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19.

Original language	English
Journal	CELL
Volume	183
Issue number	1
Pages (from-to)	158-168.e14
ISSN	0092-8674
DOIs	https://doi.org/10.1016/j.cell.2020.08.017
Publication status	Published - 2020

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This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Sekine, T., Perez-Potti, A., Rivera-Ballesteros, O., Strålin, K., Gorin, J. B., Olsson, A., Llewellyn-Lacey, S., Kamal, H., Bogdanovic, G., Muschiol, S., Wullimann, D. J., Kammann, T., Emgård, J., Parrot, T., Folkesson, E., Karolinska COVID-19 Study Group, Rooyackers, O., Eriksson, L. I., Henter, J. I., ... Buggert, M. (2020). Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19. CELL, 183(1), 158-168.e14. https://doi.org/10.1016/j.cell.2020.08.017

Sekine, Takuya ; Perez-Potti, André ; Rivera-Ballesteros, Olga ; Strålin, Kristoffer ; Gorin, Jean Baptiste ; Olsson, Annika ; Llewellyn-Lacey, Sian ; Kamal, Habiba ; Bogdanovic, Gordana ; Muschiol, Sandra ; Wullimann, David J. ; Kammann, Tobias ; Emgård, Johanna ; Parrot, Tiphaine ; Folkesson, Elin ; Karolinska COVID-19 Study Group ; Rooyackers, Olav ; Eriksson, Lars I. ; Henter, Jan Inge ; Sönnerborg, Anders ; Allander, Tobias ; Albert, Jan ; Nielsen, Morten ; Klingström, Jonas ; Gredmark-Russ, Sara ; Björkström, Niklas K. ; Sandberg, Johan K. ; Price, David A. ; Ljunggren, Hans Gustaf ; Aleman, Soo ; Buggert, Marcus. / Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19. In: CELL. 2020 ; Vol. 183, No. 1. pp. 158-168.e14.

@article{a5194923e62a41d6929b9af5d84bc5d1,

title = "Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19",

abstract = "SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. Here, we systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family members, and individuals with acute or convalescent COVID-19. Acute-phase SARS-CoV-2-specific T cells displayed a highly activated cytotoxic phenotype that correlated with various clinical markers of disease severity, whereas convalescent-phase SARS-CoV-2-specific T cells were polyfunctional and displayed a stem-like memory phenotype. Importantly, SARS-CoV-2-specific T cells were detectable in antibody-seronegative exposed family members and convalescent individuals with a history of asymptomatic and mild COVID-19. Our collective dataset shows that SARS-CoV-2 elicits broadly directed and functionally replete memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19.",

author = "Takuya Sekine and Andr{\'e} Perez-Potti and Olga Rivera-Ballesteros and Kristoffer Str{\aa}lin and Gorin, {Jean Baptiste} and Annika Olsson and Sian Llewellyn-Lacey and Habiba Kamal and Gordana Bogdanovic and Sandra Muschiol and Wullimann, {David J.} and Tobias Kammann and Johanna Emg{\aa}rd and Tiphaine Parrot and Elin Folkesson and {Karolinska COVID-19 Study Group} and Olav Rooyackers and Eriksson, {Lars I.} and Henter, {Jan Inge} and Anders S{\"o}nnerborg and Tobias Allander and Jan Albert and Morten Nielsen and Jonas Klingstr{\"o}m and Sara Gredmark-Russ and Bj{\"o}rkstr{\"o}m, {Niklas K.} and Sandberg, {Johan K.} and Price, {David A.} and Ljunggren, {Hans Gustaf} and Soo Aleman and Marcus Buggert",

note = "This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).",

year = "2020",

doi = "10.1016/j.cell.2020.08.017",

language = "English",

volume = "183",

pages = "158--168.e14",

journal = "Cell",

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Sekine, T, Perez-Potti, A, Rivera-Ballesteros, O, Strålin, K, Gorin, JB, Olsson, A, Llewellyn-Lacey, S, Kamal, H, Bogdanovic, G, Muschiol, S, Wullimann, DJ, Kammann, T, Emgård, J, Parrot, T, Folkesson, E, Karolinska COVID-19 Study Group, Rooyackers, O, Eriksson, LI, Henter, JI, Sönnerborg, A, Allander, T, Albert, J, Nielsen, M, Klingström, J, Gredmark-Russ, S, Björkström, NK, Sandberg, JK, Price, DA, Ljunggren, HG, Aleman, S & Buggert, M 2020, 'Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19', CELL, vol. 183, no. 1, pp. 158-168.e14. https://doi.org/10.1016/j.cell.2020.08.017

Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19. / Sekine, Takuya; Perez-Potti, André; Rivera-Ballesteros, Olga; Strålin, Kristoffer; Gorin, Jean Baptiste; Olsson, Annika; Llewellyn-Lacey, Sian; Kamal, Habiba; Bogdanovic, Gordana; Muschiol, Sandra; Wullimann, David J.; Kammann, Tobias; Emgård, Johanna; Parrot, Tiphaine; Folkesson, Elin; Karolinska COVID-19 Study Group; Rooyackers, Olav; Eriksson, Lars I.; Henter, Jan Inge; Sönnerborg, Anders; Allander, Tobias; Albert, Jan; Nielsen, Morten; Klingström, Jonas; Gredmark-Russ, Sara; Björkström, Niklas K.; Sandberg, Johan K.; Price, David A.; Ljunggren, Hans Gustaf; Aleman, Soo; Buggert, Marcus.

In: CELL, Vol. 183, No. 1, 2020, p. 158-168.e14.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19

AU - Sekine, Takuya

AU - Perez-Potti, André

AU - Rivera-Ballesteros, Olga

AU - Strålin, Kristoffer

AU - Gorin, Jean Baptiste

AU - Olsson, Annika

AU - Llewellyn-Lacey, Sian

AU - Kamal, Habiba

AU - Bogdanovic, Gordana

AU - Muschiol, Sandra

AU - Wullimann, David J.

AU - Kammann, Tobias

AU - Emgård, Johanna

AU - Parrot, Tiphaine

AU - Folkesson, Elin

AU - Karolinska COVID-19 Study Group

AU - Rooyackers, Olav

AU - Eriksson, Lars I.

AU - Henter, Jan Inge

AU - Sönnerborg, Anders

AU - Allander, Tobias

AU - Albert, Jan

AU - Nielsen, Morten

AU - Klingström, Jonas

AU - Gredmark-Russ, Sara

AU - Björkström, Niklas K.

AU - Sandberg, Johan K.

AU - Price, David A.

AU - Ljunggren, Hans Gustaf

AU - Aleman, Soo

AU - Buggert, Marcus

N1 - This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PY - 2020

Y1 - 2020

N2 - SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. Here, we systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family members, and individuals with acute or convalescent COVID-19. Acute-phase SARS-CoV-2-specific T cells displayed a highly activated cytotoxic phenotype that correlated with various clinical markers of disease severity, whereas convalescent-phase SARS-CoV-2-specific T cells were polyfunctional and displayed a stem-like memory phenotype. Importantly, SARS-CoV-2-specific T cells were detectable in antibody-seronegative exposed family members and convalescent individuals with a history of asymptomatic and mild COVID-19. Our collective dataset shows that SARS-CoV-2 elicits broadly directed and functionally replete memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19.

AB - SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. Here, we systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family members, and individuals with acute or convalescent COVID-19. Acute-phase SARS-CoV-2-specific T cells displayed a highly activated cytotoxic phenotype that correlated with various clinical markers of disease severity, whereas convalescent-phase SARS-CoV-2-specific T cells were polyfunctional and displayed a stem-like memory phenotype. Importantly, SARS-CoV-2-specific T cells were detectable in antibody-seronegative exposed family members and convalescent individuals with a history of asymptomatic and mild COVID-19. Our collective dataset shows that SARS-CoV-2 elicits broadly directed and functionally replete memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19.

U2 - 10.1016/j.cell.2020.08.017

DO - 10.1016/j.cell.2020.08.017

M3 - Journal article

C2 - 32979941

VL - 183

SP - 158-168.e14

JO - Cell

JF - Cell

SN - 0092-8674

IS - 1

ER -