Robust microbubble tracking for super resolution imaging in ultrasound

Kristoffer B. Hansen, Carlos Armando Villagómez Hoyos, Jens Christian Brasen, Konstantinos Diamantis, Vassilis Sboros, Charlotte Mehlin Sorensen, Jørgen Arendt Jensen

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    Abstract

    Currently ultrasound resolution is limited by diffraction to approximately half the wavelength of the sound wave employed. In recent years, super resolution imaging techniques have overcome the diffraction limit through the localization and tracking of a sparse set of microbubbles through the vasculature. However, this has only been performed on fixated tissue, limiting its clinical application. This paper proposes a technique for making super resolution images on non-fixated tissue by first compensating for tissue movement and then tracking the individual microbubbles. The experiment is performed on the kidney of a anesthetized Sprage-Dawley rat by infusing SonoVue at 0.1× original concentration. The algorithm demonstrated in vivo that the motion compensation was capable of removing the movement caused by the mechanical ventilator. The results shows that microbubbles were localized with a higher precision, reducing the standard deviation of the super localizations from 22μm to 8 μm. The paper proves that the restriction of completely fixated tissue can be eliminated, when making super resolution imaging with microbubbles.
    Original languageEnglish
    Title of host publicationProceedings of 2016 IEEE International Ultrasonics Symposium
    Number of pages4
    PublisherIEEE
    Publication date2016
    ISBN (Print)978-1-4673-9897-8
    DOIs
    Publication statusPublished - 2016
    Event2016 IEEE International Ultrasonics Symposium - Convention Center Vinci Tours, Tours, France
    Duration: 18 Sept 201621 Sept 2016
    https://ieeexplore.ieee.org/xpl/conhome/7589760/proceeding

    Conference

    Conference2016 IEEE International Ultrasonics Symposium
    LocationConvention Center Vinci Tours
    Country/TerritoryFrance
    CityTours
    Period18/09/201621/09/2016
    Internet address

    Keywords

    • Sonic and ultrasonic radiation (medical uses)
    • Patient diagnostic methods and instrumentation
    • Sonic and ultrasonic radiation (biomedical imaging/measurement)
    • Sonic and ultrasonic applications
    • Biology and medical computing
    • Computer vision and image processing techniques
    • biomedical ultrasonics
    • blood vessels
    • bubbles
    • image resolution
    • kidney
    • medical image processing
    • motion compensation
    • robust microbubble tracking
    • super resolution imaging
    • ultrasound imaging
    • sound wave
    • diffraction limit
    • vasculature
    • tissue movement
    • anesthetized Sprage-Dawley rat
    • SonoVue
    • mechanical ventilator
    • Tracking
    • Motion compensation
    • Image resolution
    • Kidney
    • Ultrasonic imaging
    • In vivo
    • Standards

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