RNA trafficking and subcellular localization-a review of mechanisms, experimental and predictive methodologies

Jun Wang*, Marc Horlacher, Lixin Cheng, Ole Winther

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

RNA localization is essential for regulating spatial translation, where RNAs are trafficked to their target locations via various biological mechanisms. In this review, we discuss RNA localization in the context of molecular mechanisms, experimental techniques and machine learning-based prediction tools. Three main types of molecular mechanisms that control the localization of RNA to distinct cellular compartments are reviewed, including directed transport, protection from mRNA degradation, as well as diffusion and local entrapment. Advances in experimental methods, both image and sequence based, provide substantial data resources, which allow for the design of powerful machine learning models to predict RNA localizations. We review the publicly available predictive tools to serve as a guide for users and inspire developers to build more effective prediction models. Finally, we provide an overview of multimodal learning, which may provide a new avenue for the prediction of RNA localization.
Original languageEnglish
Article numberbbad249
JournalBriefings in Bioinformatics
Number of pages14
ISSN1467-5463
DOIs
Publication statusPublished - 2023

Keywords

  • RNA
  • Localization
  • Machine learning
  • Multimodality
  • Subcellular

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