RNA-seq based expression analysis of the CHO cell protein secretion pathway

Anne Mathilde Lund, Christian Schrøder Kaas, Helene Faustrup Kildegaard, Claus Kristensen, Mikael Rørdam Andersen

Research output: Contribution to conferencePosterResearchpeer-review

568 Downloads (Pure)

Abstract

The Chinese hamster ovary (CHO) cell-line is the predominant mammalian industrial cell line being used to produce recombinant therapeutic proteins. Although CHO cells have been used for more than 25 years, the genome sequence was first published in 2011. So far there have been limited studies of the cell biology of the CHO cell and the potential of cell line engineering. To elucidate the poorly understood cellular processes that control and limit recombinant protein production and secretion, a system-wide study was initiated to identify possible engineering targets relevant for therapeutic protein production.
Original languageEnglish
Publication date2013
Publication statusPublished - 2013
Event3rd Annual Next Generation Sequencing Asia Congress - Singapore, Singapore
Duration: 8 Oct 20139 Oct 2013

Conference

Conference3rd Annual Next Generation Sequencing Asia Congress
CountrySingapore
CitySingapore
Period08/10/201309/10/2013

Fingerprint

Dive into the research topics of 'RNA-seq based expression analysis of the CHO cell protein secretion pathway'. Together they form a unique fingerprint.

Cite this