Rhamnogalacturonan II - Chemical Synthesis of a Substructure Including α-2,3-Linked Kdo

Enzo Mancuso; Cecilia Romanò; Nino Trattnig; Philipp Gritsch; Paul Kosma; Mads Hartvig Clausen

doi:10.1002/chem.202100837

Rhamnogalacturonan II - Chemical Synthesis of a Substructure Including α-2,3-Linked Kdo

Enzo Mancuso, Cecilia Romanò^*, Nino Trattnig, Philipp Gritsch, Paul Kosma, Mads Hartvig Clausen^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

The synthesis of a fully deprotected Kdo-containing rhamnogalacturonan II pentasaccharide is described. The strategy relies on the preparation of a suitably protected homogalacturonan tetrasaccharide backbone through a post-glycosylation oxidation approach, and its stereoselective glycosylation with a Kdo fluoride donor.

Original language	English
Journal	Chemistry - A European Journal
Volume	27
Issue number	24
Pages (from-to)	7099-7102
ISSN	0947-6539
DOIs	https://doi.org/10.1002/chem.202100837
Publication status	Published - 2021

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title = "Rhamnogalacturonan II - Chemical Synthesis of a Substructure Including α-2,3-Linked Kdo",

abstract = "The synthesis of a fully deprotected Kdo-containing rhamnogalacturonan II pentasaccharide is described. The strategy relies on the preparation of a suitably protected homogalacturonan tetrasaccharide backbone through a post-glycosylation oxidation approach, and its stereoselective glycosylation with a Kdo fluoride donor.",

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T1 - Rhamnogalacturonan II - Chemical Synthesis of a Substructure Including α-2,3-Linked Kdo

AU - Mancuso, Enzo

AU - Romanò, Cecilia

AU - Trattnig, Nino

AU - Gritsch, Philipp

AU - Kosma, Paul

AU - Clausen, Mads Hartvig

PY - 2021

Y1 - 2021

N2 - The synthesis of a fully deprotected Kdo-containing rhamnogalacturonan II pentasaccharide is described. The strategy relies on the preparation of a suitably protected homogalacturonan tetrasaccharide backbone through a post-glycosylation oxidation approach, and its stereoselective glycosylation with a Kdo fluoride donor.

AB - The synthesis of a fully deprotected Kdo-containing rhamnogalacturonan II pentasaccharide is described. The strategy relies on the preparation of a suitably protected homogalacturonan tetrasaccharide backbone through a post-glycosylation oxidation approach, and its stereoselective glycosylation with a Kdo fluoride donor.

U2 - 10.1002/chem.202100837

DO - 10.1002/chem.202100837

M3 - Journal article

C2 - 33769639

SN - 0947-6539

VL - 27

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EP - 7102

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

IS - 24

ER -

Rhamnogalacturonan II - Chemical Synthesis of a Substructure Including α-2,3-Linked Kdo

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