Review of Oxepine-Pyrimidinone-Ketopiperazine Type Nonribosomal Peptides

Yaojie Guo; Jens C. Frisvad; Thomas O. Larsen

doi:10.3390/metabo10060246

Review of Oxepine-Pyrimidinone-Ketopiperazine Type Nonribosomal Peptides

Yaojie Guo, Jens C. Frisvad, Thomas O. Larsen^*

^*Corresponding author for this work

Research output: Contribution to journal › Review › peer-review

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Abstract

Recently, a rare class of nonribosomal peptides (NRPs) bearing a unique Oxepine-Pyrimidinone-Ketopiperazine (OPK) scaffold has been exclusively isolated from fungal sources. Based on the number of rings and conjugation systems on the backbone, it can be further categorized into three types A, B, and C. These compounds have been applied to various bioassays, and some have exhibited promising bioactivities like antifungal activity against phytopathogenic fungi and transcriptional activation on liver X receptor α. This review summarizes all the research related to natural OPK NRPs, including their biological sources, chemical structures, bioassays, as well as proposed biosynthetic mechanisms from 1988 to March 2020. The taxonomy of the fungal sources and chirality-related issues of these products are also discussed.

Original language	English
Article number	246
Journal	Metabolites
Volume	10
Issue number	6
Number of pages	13
ISSN	2218-1989
DOIs	https://doi.org/10.3390/metabo10060246
Publication status	Published - 2020

Keywords

Oxepine
Nonribosomal peptides
Bioactivity
Biosynthesis
Fungi
Aspergillus

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abstract = "Recently, a rare class of nonribosomal peptides (NRPs) bearing a unique Oxepine-Pyrimidinone-Ketopiperazine (OPK) scaffold has been exclusively isolated from fungal sources. Based on the number of rings and conjugation systems on the backbone, it can be further categorized into three types A, B, and C. These compounds have been applied to various bioassays, and some have exhibited promising bioactivities like antifungal activity against phytopathogenic fungi and transcriptional activation on liver X receptor α. This review summarizes all the research related to natural OPK NRPs, including their biological sources, chemical structures, bioassays, as well as proposed biosynthetic mechanisms from 1988 to March 2020. The taxonomy of the fungal sources and chirality-related issues of these products are also discussed.",

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AU - Larsen, Thomas O.

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AB - Recently, a rare class of nonribosomal peptides (NRPs) bearing a unique Oxepine-Pyrimidinone-Ketopiperazine (OPK) scaffold has been exclusively isolated from fungal sources. Based on the number of rings and conjugation systems on the backbone, it can be further categorized into three types A, B, and C. These compounds have been applied to various bioassays, and some have exhibited promising bioactivities like antifungal activity against phytopathogenic fungi and transcriptional activation on liver X receptor α. This review summarizes all the research related to natural OPK NRPs, including their biological sources, chemical structures, bioassays, as well as proposed biosynthetic mechanisms from 1988 to March 2020. The taxonomy of the fungal sources and chirality-related issues of these products are also discussed.

KW - Oxepine

KW - Nonribosomal peptides

KW - Bioactivity

KW - Biosynthesis

KW - Fungi

KW - Aspergillus

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DO - 10.3390/metabo10060246

M3 - Review

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JO - Metabolites

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ER -

Review of Oxepine-Pyrimidinone-Ketopiperazine Type Nonribosomal Peptides

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