Retinoic Acid Signaling in Stromal Cells Regulates Intestinal Lymphoid Tissue Stromal Development

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Intestinal lymphoid tissues such as Peyer ́s patches (PP) and intestine-draining mesenteric lymph nodes (MLN) represent major priming sites of intestinal immune activation and are crucial for the maintenance of mucosal immune homeostasis. The architecture of these lymphoid tissues is preserved by a complex three-dimensional network of distinct mesenchyme-derived stromal cells (SC) residing in different environments within the tissue. Besides providing a scaffold to optimize immune cell interactions SC produce key immune cell migratory and survival cues and are thus increasingly recognized as essential regulators of intestinal immune function.
Vitamin A is obtained through the diet and its metabolite, retinoic acid (RA), has emerged as a key regulator of intestinal immune responses by directly inducing gut-tropic T and B cells in PP and MLN, driving de novo generation of regulatory T cells and promoting IgA production. Despite these findings, the impact of RA signaling in intestinal lymphoid SC on PP and MLN SC development and the consequence of these signals on intestinal immune responses remains completely unknown.
To gain a better understanding of the impact of RA signaling in SC we have generated mice whose intestinal lymphoid SC fail to respond to RA. Our preliminary data suggest that the lack of SC-specific RA signaling alters the SC compartment of PP and MLN. Further studies aim to assess the potential role of SC-specific RA signaling in intestinal immune homeostasis and during inflammation.
Original languageEnglish
Publication date2018
Publication statusPublished - 2018
EventMucosal Immunology Course & Symposium 2018 - Oxford, United Kingdom
Duration: 17 Jul 201820 Jul 2018
Conference number: 2

Conference

ConferenceMucosal Immunology Course & Symposium 2018
Number2
CountryUnited Kingdom
CityOxford
Period17/07/201820/07/2018
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