Response to Comment on "Positive Selection of Tyrosine Loss in Metazoan Evolution"

Chris Soon Heng Tan; Erwin Schoof; Pau Creixell; Adrian Pasculescu; Wendell A. Lim; Tony Pawson; Gary D. Bader; Rune Linding

doi:10.1126/science.1188535

Response to Comment on "Positive Selection of Tyrosine Loss in Metazoan Evolution"

Chris Soon Heng Tan, Erwin Schoof, Pau Creixell, Adrian Pasculescu, Wendell A. Lim, Tony Pawson, Gary D. Bader, Rune Linding

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Su et al. claim guanine-cytosine (GC) content variation can largely explain the observed tyrosine frequency variation, independent of adaptive evolution of cell-signaling complexity. We found that GC content variation, in the absence of selection for amino acid changes, can only maximally account for 38% of the observed tyrosine frequency variation. We also uncovered other mechanisms acting to reduce tyrosine phosphorylation that further support our previous proposal.

Original language	English
Journal	Science
Volume	332
Issue number	6032
Pages (from-to)	917
ISSN	0036-8075
DOIs	https://doi.org/10.1126/science.1188535
Publication status	Published - 2011

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title = "Response to Comment on {"}Positive Selection of Tyrosine Loss in Metazoan Evolution{"}",

abstract = "Su et al. claim guanine-cytosine (GC) content variation can largely explain the observed tyrosine frequency variation, independent of adaptive evolution of cell-signaling complexity. We found that GC content variation, in the absence of selection for amino acid changes, can only maximally account for 38% of the observed tyrosine frequency variation. We also uncovered other mechanisms acting to reduce tyrosine phosphorylation that further support our previous proposal.",

author = "Tan, {Chris Soon Heng} and Erwin Schoof and Pau Creixell and Adrian Pasculescu and Lim, {Wendell A.} and Tony Pawson and Bader, {Gary D.} and Rune Linding",

year = "2011",

doi = "10.1126/science.1188535",

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journal = "Science",

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publisher = "American Association for the Advancement of Science",

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AU - Tan, Chris Soon Heng

AU - Schoof, Erwin

AU - Creixell, Pau

AU - Pasculescu, Adrian

AU - Lim, Wendell A.

AU - Pawson, Tony

AU - Bader, Gary D.

AU - Linding, Rune

PY - 2011

Y1 - 2011

N2 - Su et al. claim guanine-cytosine (GC) content variation can largely explain the observed tyrosine frequency variation, independent of adaptive evolution of cell-signaling complexity. We found that GC content variation, in the absence of selection for amino acid changes, can only maximally account for 38% of the observed tyrosine frequency variation. We also uncovered other mechanisms acting to reduce tyrosine phosphorylation that further support our previous proposal.

AB - Su et al. claim guanine-cytosine (GC) content variation can largely explain the observed tyrosine frequency variation, independent of adaptive evolution of cell-signaling complexity. We found that GC content variation, in the absence of selection for amino acid changes, can only maximally account for 38% of the observed tyrosine frequency variation. We also uncovered other mechanisms acting to reduce tyrosine phosphorylation that further support our previous proposal.

U2 - 10.1126/science.1188535

DO - 10.1126/science.1188535

M3 - Journal article

SN - 0036-8075

VL - 332

SP - 917

JO - Science

JF - Science

IS - 6032

ER -

Response to Comment on "Positive Selection of Tyrosine Loss in Metazoan Evolution"

Abstract

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