Response to Comment on "Positive Selection of Tyrosine Loss in Metazoan Evolution"

Chris Soon Heng Tan, Erwin Schoof, Pau Creixell, Adrian Pasculescu, Wendell A. Lim, Tony Pawson, Gary D. Bader, Rune Linding

    Research output: Contribution to journalJournal articleResearchpeer-review


    Su et al. claim guanine-cytosine (GC) content variation can largely explain the observed tyrosine frequency variation, independent of adaptive evolution of cell-signaling complexity. We found that GC content variation, in the absence of selection for amino acid changes, can only maximally account for 38% of the observed tyrosine frequency variation. We also uncovered other mechanisms acting to reduce tyrosine phosphorylation that further support our previous proposal.
    Original languageEnglish
    Issue number6032
    Pages (from-to)917
    Publication statusPublished - 2011


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