Reproductive and behavioral effects of diisononyl phthalate (DINP) in perinatally exposed rats

Research output: Contribution to journalJournal article – Annual report year: 2011Researchpeer-review

View graph of relations

Diisononyl phthalate (DINP) is a plasticizer abundantly used in consumer products as a substitute for other plasticizers prohibited in certain products due to reproductive toxicity. As anti-androgenic effects of DINP are suspected, DINP effects on reproduction and sexually dimorphic behavior were studied.Pregnant Wistar rats were gavaged from gestation day 7 to postnatal day (PND) 17 with vehicle, 300, 600, 750 or 900mg DINP/kg bw/day.In fetal testes histopathological effects typical of phthalates were observed. In male offspring, DINP caused increased nipple retention, reduced anogenital distance, reduced sperm motility and increased sperm count. DINP affected spatial learning as female offspring performed better than controls and similarly to control males in the Morris Water Maze, indicating masculinization of behavior in DINP exposed females.These results show that DINP causes anti-androgenic effects on reproductive development, though less potent than DEHP, DBP and BBP, and further safety evaluation of DINP appears warranted.
Original languageEnglish
JournalReproductive Toxicology
Volume31
Issue number2
Pages (from-to)200-209
ISSN0890-6238
DOIs
Publication statusPublished - 2011
CitationsWeb of Science® Times Cited: No match on DOI

    Research areas

  • Rat, Behavior, Semen quality, Phthalate, Toxicity, Anti-androgenic

Download statistics

No data available

ID: 5563885