Purpose: To study hyperpolarized water as an angiographyand perfusion tracer in a large animal model.Methods: Protons dissolved in deuterium oxide (D2O) werehyperpolarized in a SPINlab dissolution dynamic nuclear polari-zation (dDNP) polarizer and subsequently investigated in vivo ina pig model at 3 Tesla (T). Approximately 15 mL of hyperpolar-ized water was injected in the renal artery by hand over 4–5 s.Results: A liquid state polarization of 5.3 6 0.9% of 3.8 M pro-tons in 15 mL of deuterium oxide was achieved with a T1of24 6 1 s. This allowed injection through an arterial catheterinto the renal artery and subsequently high-contrast imaging ofthe entire kidney parenchyma over several seconds. Thedynamic images allow quantification of tissue perfusion, with amean cortical perfusion of 504 6 123 mL/100 mL/min.Conclusion: Hyperpolarized water MR imaging was success-fully demonstrated as a renal angiography and perfusion meth-od. Quantitative perfusion maps of the kidney were obtainedin agreement with literature and control experiments with gad-olinium contrast.
- Magnetic resonance angiography
Lipsø, H. K. W., Hansen, E. S. S., Tougaard, R. S., Laustsen, C., & Ardenkjær-Larsen, J. H. (2017). Renal MR angiography and perfusion in the pig using hyperpolarized water. Magnetic Resonance in Medicine, 78(3), 1131-1135. https://doi.org/10.1002/mrm.26478