Renal Impairment Hampers Bisphosphonate Treatment in a Quarter of Lung Cancer Patients with Bone Metastasis

Katalin Fabian; Rita Puskás; Tímea Kakuk; László Prés; Dorottya Fejes; Zsolt Szegedi; Lívia Rojkó; Zoltan Imre Szallasi; Balázs Döme; Orsolya Pipek; Judit Moldvay

doi:10.1111/bcpt.12876

Renal Impairment Hampers Bisphosphonate Treatment in a Quarter of Lung Cancer Patients with Bone Metastasis

Katalin Fabian
, Rita Puskás
, Tímea Kakuk
, László Prés
, Dorottya Fejes
, Zsolt Szegedi
, Lívia Rojkó
, Zoltan Imre Szallasi
, Balázs Döme
, Orsolya Pipek
, Judit Moldvay^*

^*Corresponding author for this work

Semmelweis University
National Korányi Institute of TB and Pulmonology
Eötvös Loránd University

Research output: Contribution to journal › Journal article › Research › peer-review

329 Downloads (Orbit)

Abstract

Renal function impairment in lung cancer patients with bone metastases was investigated, as this can limit the application of bisphosphonates representing the gold standard in the management of such cases. Clinicopathological data of 570 lung cancer patients were retrospectively analysed for changes in renal function parameters. Co-morbidities included hypertension (50%), COPD (33%) and diabetes mellitus (15%). Statistical analysis was performed with Fisher's exact tests and a Cox proportional hazards model. In patients suffering from hypertension, both median serum creatinine and blood urea nitrogen (BUN) were higher (81.9 versus 75.8 μmol/l, p

Original language	English
Journal	Basic and Clinical Pharmacology and Toxicology
Volume	122
Issue number	1
Pages (from-to)	126-132
ISSN	1742-7835
DOIs	https://doi.org/10.1111/bcpt.12876
Publication status	Published - 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Lung cancer
Bisphosphonate treatment
Bone metastasis
Renal function

Access to Document

10.1111/bcpt.12876

RenalAccepted author manuscript, 357 KB

OpenUrl availability

Check availability in DTU Findit

Cite this

@article{82a9eb2fa7104a11bb84274633a4ac11,

title = "Renal Impairment Hampers Bisphosphonate Treatment in a Quarter of Lung Cancer Patients with Bone Metastasis",

abstract = "Renal function impairment in lung cancer patients with bone metastases was investigated, as this can limit the application of bisphosphonates representing the gold standard in the management of such cases. Clinicopathological data of 570 lung cancer patients were retrospectively analysed for changes in renal function parameters. Co-morbidities included hypertension (50\%), COPD (33\%) and diabetes mellitus (15\%). Statistical analysis was performed with Fisher's exact tests and a Cox proportional hazards model. In patients suffering from hypertension, both median serum creatinine and blood urea nitrogen (BUN) were higher (81.9 versus 75.8 μmol/l, p",

keywords = "Lung cancer, Bisphosphonate treatment, Bone metastasis, Renal function",

author = "Katalin Fabian and Rita Pusk{\'a}s and T{\'i}mea Kakuk and L{\'a}szl{\'o} Pr{\'e}s and Dorottya Fejes and Zsolt Szegedi and L{\'i}via Rojk{\'o} and Szallasi, \{Zoltan Imre\} and Bal{\'a}zs D{\"o}me and Orsolya Pipek and Judit Moldvay",

year = "2017",

doi = "10.1111/bcpt.12876",

language = "English",

volume = "122",

pages = "126--132",

journal = "Basic and Clinical Pharmacology and Toxicology",

issn = "1742-7835",

publisher = "Wiley",

number = "1",

}

TY - JOUR

T1 - Renal Impairment Hampers Bisphosphonate Treatment in a Quarter of Lung Cancer Patients with Bone Metastasis

AU - Fabian, Katalin

AU - Puskás, Rita

AU - Kakuk, Tímea

AU - Prés, László

AU - Fejes, Dorottya

AU - Szegedi, Zsolt

AU - Rojkó, Lívia

AU - Szallasi, Zoltan Imre

AU - Döme, Balázs

AU - Pipek, Orsolya

AU - Moldvay, Judit

PY - 2017

Y1 - 2017

N2 - Renal function impairment in lung cancer patients with bone metastases was investigated, as this can limit the application of bisphosphonates representing the gold standard in the management of such cases. Clinicopathological data of 570 lung cancer patients were retrospectively analysed for changes in renal function parameters. Co-morbidities included hypertension (50%), COPD (33%) and diabetes mellitus (15%). Statistical analysis was performed with Fisher's exact tests and a Cox proportional hazards model. In patients suffering from hypertension, both median serum creatinine and blood urea nitrogen (BUN) were higher (81.9 versus 75.8 μmol/l, p

AB - Renal function impairment in lung cancer patients with bone metastases was investigated, as this can limit the application of bisphosphonates representing the gold standard in the management of such cases. Clinicopathological data of 570 lung cancer patients were retrospectively analysed for changes in renal function parameters. Co-morbidities included hypertension (50%), COPD (33%) and diabetes mellitus (15%). Statistical analysis was performed with Fisher's exact tests and a Cox proportional hazards model. In patients suffering from hypertension, both median serum creatinine and blood urea nitrogen (BUN) were higher (81.9 versus 75.8 μmol/l, p

KW - Lung cancer

KW - Bisphosphonate treatment

KW - Bone metastasis

KW - Renal function

U2 - 10.1111/bcpt.12876

DO - 10.1111/bcpt.12876

M3 - Journal article

C2 - 28834230

SN - 1742-7835

VL - 122

SP - 126

EP - 132

JO - Basic and Clinical Pharmacology and Toxicology

JF - Basic and Clinical Pharmacology and Toxicology

IS - 1

ER -

Renal Impairment Hampers Bisphosphonate Treatment in a Quarter of Lung Cancer Patients with Bone Metastasis

Abstract

UN SDGs

Keywords

Access to Document

OpenUrl availability

Fingerprint

Cite this