Abstract
Abnormal skeleton muscle activity during REM
sleep is characterized as REM Behaviour Disorder (RBD),
and may be an early marker for different neurodegenerative
diseases. Early detection of RBD is therefore highly important,
and in this ongoing study a semi-automatic method for RBD
detection is proposed by analyzing the motor activity during
sleep. Method: A total number of twelve patients have been
involved in this study, six normal controls and six patients
diagnosed with Parkinsons Disease (PD) with RBD. All subjects
underwent at least one ambulant polysomnographic (PSG)
recording. The sleep recordings were scored, according to
the new sleep-scoring standard from the American Academy
of Sleep Medicine, by two independent sleep specialists. A
follow-up analysis of the scoring consensus between the two
specialists has been conducted. Based on the agreement of
the two manual scorings, a computerized algorithm has been
attempted implemented. By analysing the REM and non-REM
EMG activity, using advanced signal processing tools combined
with a statistical classifier, it is possible to discriminate normal
and abnormal EMG activity. Due to the small number of patients,
the overall performance of the algorithm was calculated
using the leave-one-out approach and benchmarked against
a previously published computerized/visual method. Results:
Based on the available data and using optimal settings, it was
possible to correctly classify PD subjects with RBD with 100%
sensitivity, 100% specificity, which is an improvement compared
to previous published studies. Conclusion: The overall result
indicates the usefulness of a computerized scoring algorithm
and may be a feasible way of reducing scoring time. Further
enhancement on additional data, i.e. subjects with idiopathic
RBD (iRBD) and PD without RBD, is needed to validate its
robustness and the overall result.
Original language | English |
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Title of host publication | 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) |
Publisher | IEEE |
Publication date | 2010 |
Pages | 5093-5096 |
ISBN (Print) | 978-1-4244-4123-5 |
DOIs | |
Publication status | Published - 2010 |
Event | 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Buenos Aires, Argentina Duration: 31 Aug 2010 → 4 Sept 2010 Conference number: 32 http://embc2010.embs.org/ |
Conference
Conference | 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society |
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Number | 32 |
Country/Territory | Argentina |
City | Buenos Aires |
Period | 31/08/2010 → 04/09/2010 |
Internet address |
Series | I E E E Engineering in Medicine and Biology Society. Conference Proceedings |
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ISSN | 2375-7477 |