With the increased need for multi-center magnetic resonance imaging studies, problems arise related to differences in hardware and software between centers. Namely, current algorithms for brain volume quantification are unreliable for the longitudinal assessment of volume changes in this type of setting. Currently most methods attempt to decrease this issue by regressing the scanner- and/or center-effects from the original data. In this work, we explore a novel approach to harmonize brain volume measurements by using only image descriptors. First, we explore the relationships between volumes and image descriptors. Then, we train a Relevance Vector Machine (RVM) model over a large multi-site dataset of healthy subjects to perform volume harmonization. Finally, we validate the method over two different datasets: (i) a subset of unseen healthy controls; and (ii) a test-retest dataset of multiple sclerosis (MS) patients. The method decreases scanner and center variability while preserving measurements that did not require correction in MS patient data. We show that image descriptors can be used as input to a machine learning algorithm to improve the reliability of longitudinal volumetric studies.
|Title of host publication||OR 2.0 Context-Aware Operating Theaters and Machine Learning in Clinical Neuroimaging : Proceedings of Second International Workshop, OR 2.0 2019, and Second International Workshop, MLCN 2019|
|Publication status||Published - 2019|
|Series||Lecture Notes in Computer Science|
Meyer, M. I., Rosa, E., Leemput, K., & Sima, D. (2019). Relevance Vector Machines for Harmonization of MRI Brain Volumes Using Image Descriptors. In OR 2.0 Context-Aware Operating Theaters and Machine Learning in Clinical Neuroimaging: Proceedings of Second International Workshop, OR 2.0 2019, and Second International Workshop, MLCN 2019 (pp. 77-85). Springer. Lecture Notes in Computer Science, Vol.. 11796 https://doi.org/10.1007/978-3-030-32695-1_9