Relative bioavailability of the flavonoids quercetin, hesperetin and naringenin given simultaneously through diet

Kirstine Suszkiewicz Krogholm, Lea Bredsdorff, Pia Knuthsen, J. Haraldsdottir, S. E Rasmussen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The bioavailability and urinary excretion of three dietary flavonoids, quercetin, hesperetin and naringenin, were investigated. Ten healthy men were asked to consume a 'juice mix' containing equal amounts of the three flavonoids, and their urine and plasma samples were collected. The resulting mean plasma area under the curve (AUC)(0-48h) and C-max values for quercetin and hesperetin were similar, whereas the AUC(0-48h) of naringenin and, thus, the relative bioavailability were higher after consumption of the same dose. The study consolidates a significantly lower urinary excretion of quercetin (1.5 +/- 1%) compared with hesperetin (14.2 +/- 9.1%) and naringenin (22.6 +/- 11.5%) and shows that this is not due to a lower bioavailability of quercetin, but rather reflects different clearance mechanisms. European Journal of Clinical Nutrition (2010) 64, 432-435; doi: 10.1038/ejcn.2010.6; published online 3 February 2010
Original languageEnglish
JournalEuropean Journal of Clinical Nutrition
Volume64
Issue number4
Pages (from-to)432-435
ISSN0954-3007
DOIs
Publication statusPublished - 2010

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