Regionalized Development and Maintenance of the Intestinal Adaptive Immune Landscape

William Winston Agace; Kathy D. McCoy

doi:10.1016/j.immuni.2017.04.004

Regionalized Development and Maintenance of the Intestinal Adaptive Immune Landscape

William Winston Agace, Kathy D. McCoy

University of Calgary

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Abstract

The intestinal immune system has the daunting task of protecting us from pathogenic insults while limiting inflammatory responses against the resident commensal microbiota and providing tolerance to food antigens. This role is particularly impressive when one considers the vast mucosal surface and changing landscape that the intestinal immune system must monitor. In this review, we highlight regional differences in the development and composition of the adaptive immune landscape of the intestine and the impact of local intrinsic and environmental factors that shape this process. To conclude, we review the evidence for a critical window of opportunity for early-life exposures that affect immune development and alter disease susceptibility later in life.

Original language	English
Journal	Immunity
Volume	46
Issue number	4
Pages (from-to)	532-548
Number of pages	17
ISSN	1074-7613
DOIs	https://doi.org/10.1016/j.immuni.2017.04.004
Publication status	Published - 2017

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abstract = "The intestinal immune system has the daunting task of protecting us from pathogenic insults while limiting inflammatory responses against the resident commensal microbiota and providing tolerance to food antigens. This role is particularly impressive when one considers the vast mucosal surface and changing landscape that the intestinal immune system must monitor. In this review, we highlight regional differences in the development and composition of the adaptive immune landscape of the intestine and the impact of local intrinsic and environmental factors that shape this process. To conclude, we review the evidence for a critical window of opportunity for early-life exposures that affect immune development and alter disease susceptibility later in life.",

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AB - The intestinal immune system has the daunting task of protecting us from pathogenic insults while limiting inflammatory responses against the resident commensal microbiota and providing tolerance to food antigens. This role is particularly impressive when one considers the vast mucosal surface and changing landscape that the intestinal immune system must monitor. In this review, we highlight regional differences in the development and composition of the adaptive immune landscape of the intestine and the impact of local intrinsic and environmental factors that shape this process. To conclude, we review the evidence for a critical window of opportunity for early-life exposures that affect immune development and alter disease susceptibility later in life.

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Regionalized Development and Maintenance of the Intestinal Adaptive Immune Landscape

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