Regional specialization within the intestinal immune system.

Research output: Contribution to journalJournal article – Annual report year: 2014Researchpeer-review

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Regional specialization within the intestinal immune system. / Mowat, Allan M.; Agace, William Winston.

In: Nature Reviews. Immunology, Vol. 14, No. 10, 2014, p. 667-685.

Research output: Contribution to journalJournal article – Annual report year: 2014Researchpeer-review

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@article{571c13b6f5c74f2680507bf24c84f968,
title = "Regional specialization within the intestinal immune system.",
abstract = "The intestine represents the largest compartment of the immune system. It is continually exposed to antigens and immunomodulatory agents from the diet and the commensal microbiota, and it is the port of entry for many clinically important pathogens. Intestinal immune processes are also increasingly implicated in controlling disease development elsewhere in the body. In this Review, we detail the anatomical and physiological distinctions that are observed in the small and large intestines, and we suggest how these may account for the diversity in the immune apparatus that is seen throughout the intestine. We describe how the distribution of innate, adaptive and innate-like immune cells varies in different segments of the intestine and discuss the environmental factors that may influence this. Finally, we consider the implications of regional immune specialization for inflammatory disease in the intestine.",
author = "Mowat, {Allan M.} and Agace, {William Winston}",
year = "2014",
doi = "10.1038/nri3738",
language = "English",
volume = "14",
pages = "667--685",
journal = "Nature Reviews. Immunology",
issn = "1474-1733",
publisher = "Nature Publishing Group",
number = "10",

}

RIS

TY - JOUR

T1 - Regional specialization within the intestinal immune system.

AU - Mowat, Allan M.

AU - Agace, William Winston

PY - 2014

Y1 - 2014

N2 - The intestine represents the largest compartment of the immune system. It is continually exposed to antigens and immunomodulatory agents from the diet and the commensal microbiota, and it is the port of entry for many clinically important pathogens. Intestinal immune processes are also increasingly implicated in controlling disease development elsewhere in the body. In this Review, we detail the anatomical and physiological distinctions that are observed in the small and large intestines, and we suggest how these may account for the diversity in the immune apparatus that is seen throughout the intestine. We describe how the distribution of innate, adaptive and innate-like immune cells varies in different segments of the intestine and discuss the environmental factors that may influence this. Finally, we consider the implications of regional immune specialization for inflammatory disease in the intestine.

AB - The intestine represents the largest compartment of the immune system. It is continually exposed to antigens and immunomodulatory agents from the diet and the commensal microbiota, and it is the port of entry for many clinically important pathogens. Intestinal immune processes are also increasingly implicated in controlling disease development elsewhere in the body. In this Review, we detail the anatomical and physiological distinctions that are observed in the small and large intestines, and we suggest how these may account for the diversity in the immune apparatus that is seen throughout the intestine. We describe how the distribution of innate, adaptive and innate-like immune cells varies in different segments of the intestine and discuss the environmental factors that may influence this. Finally, we consider the implications of regional immune specialization for inflammatory disease in the intestine.

U2 - 10.1038/nri3738

DO - 10.1038/nri3738

M3 - Journal article

VL - 14

SP - 667

EP - 685

JO - Nature Reviews. Immunology

JF - Nature Reviews. Immunology

SN - 1474-1733

IS - 10

ER -