Regional brain volumes, diffusivity, and metabolite changes after electroconvulsive therapy for severe depression

A. Jørgensen, P. Magnusson, Lars G. Hanson, T. Kirkegaard, H. Benveniste, H. Lee, C. Svarer, J. D. Mikkelsen, A. Fink-Jensen, G. M. Knudsen, O. B. Paulson, T. G. Bolwig, M. B. Jorgensen

Research output: Contribution to journalJournal articleResearchpeer-review


Objective: To investigate the role of hippocampal plasticity in the antidepressant effect of electroconvulsive therapy (ECT). Method: We used magnetic resonance (MR) imaging including diffusion tensor imaging (DTI) and proton MR spectroscopy (1 H- MRS) to investigate hippocampal volume, diffusivity, and metabolite changes in 19 patients receiving ECT for severe depression. Other regions of interest included the amygdala, dorsolateral prefrontal cortex (DLPFC), orbitofrontal cortex, and hypothalamus. Patients received a 3T MR scan before ECT (TP1), 1 week (TP2), and 4 weeks (TP3) after ECT. Results: Hippocampal and amygdala volume increased significantly at TP2 and continued to be increased at TP3. DLPFC exhibited a transient volume reduction at TP2. DTI revealed a reduced anisotropy and diffusivity of the hippocampus at TP2. We found no significant post-ECT changes in brain metabolite concentrations, and we were unable to identify a spectral signature at 1.30 ppm previously suggested to reflect neurogenesis induced by ECT. None of the brain imaging measures correlated to the clinical response. Conclusion: Our findings show that ECT causes a remodeling of brain structures involved in affective regulation, but due to their lack of correlation with the antidepressant effect, this remodeling does not appear to be directly underlying the antidepressant action of ECT
Original languageEnglish
JournalActa Psychiatrica Scandinavica
Issue number2
Pages (from-to)154–164
Number of pages11
Publication statusPublished - 2016


  • Depression
  • Electroconvulsive therapy
  • Hippocampus
  • Magnetic Resonance Imaging
  • Diffusion tensor imaging
  • Magnetic resonance spectroscopy

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