Abstract
Radical diversification: Through the discovery of diverse indolosesquiterpene dimers in a strain heterologously expressing the xiamycin biosynthesis genes, the analysis of mutants, and biotransformation studies, it has been inferred that a single flavoprotein mediates N-C and N-N aryl coupling reactions, as well as the formation of a cyclic ether (oxiamycin). Synthetic emulation of this unusual transformation provides evidence for a radical-based mechanism.
Original language | English |
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Journal | Angewandte chemie-international edition |
Volume | 52 |
Issue number | 34 |
Pages (from-to) | 9040-9043 |
Number of pages | 4 |
ISSN | 1433-7851 |
DOIs | |
Publication status | Published - 2013 |
Externally published | Yes |
Keywords
- Alkaloids
- Aryl Coupling
- Flavoproteins
- Indolosesquiterpenes
- Radicals