An efficient reductive cyclization strategy was employed for the synthesis of N‐substituted β,γ‐dihydroxy‐γ‐lactams. A subsequent Petasis‐like reaction (PLR) through nucleophilic additions of boronic acids to intermediate N‐acyliminium ions produced substituted γ‐lactams. Overall, the application of this protocol provides β,γ‐dihydroxy‐γ‐lactams and functionalized γ‐lactams with potential interest for synthetic and bioorganic chemistry.
- Reductive cyclization
- Petasis‐like reaction
- Nucleophilic addition
- Synthetic methods
Wu, P., Petersen, M. Å., Cohrt, A. E., Petersen, R., Clausen, M. H., & Nielsen, T. E. (2015). Reductive Cyclization and Petasis‐Like Reaction for the Synthesis of Functionalized γ‐Lactams. European Journal of Organic Chemistry, 2015(11), 2346-2350. https://doi.org/10.1002/ejoc.201500143