Redox-Neutral Ni-Catalyzed sp3 C-H Alkylation of α-Olefins with Unactivated Alkyl Bromides

Mikkel B. Buendia; Bradley Higginson; Søren Kegnæs; Søren Kramer; Ruben Martin

doi:10.1021/acscatal.2c01057

Redox-Neutral Ni-Catalyzed sp³C-H Alkylation of α-Olefins with Unactivated Alkyl Bromides

Mikkel B. Buendia, Bradley Higginson, Søren Kegnæs, Søren Kramer^*, Ruben Martin^*

^*Corresponding author for this work

Department of Chemistry

Institute of Chemical Research of Catalonia

Research output: Contribution to journal › Letter › peer-review

Abstract

A light-induced redox-neutral Ni-catalyzed sp³ C-H alkylation of unactivated alkenes with alkyl bromides possessing β-hydrogens is described herein. The method is distinguished by its simplicity, wide scope, and exquisite regio- and chemoselectivity profile, thus offering an entry point to forge sp³-sp³ architectures.

Original language	English
Journal	ACS Catalysis
Volume	12
Issue number	7
Pages (from-to)	3815-3820
Number of pages	6
ISSN	2155-5435
DOIs	https://doi.org/10.1021/acscatal.2c01057
Publication status	Published - 2022

Keywords

Nickel
Photochemistry
Cross-coupling
Alkylation
Olefin functionalization

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10.1021/acscatal.2c01057

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title = "Redox-Neutral Ni-Catalyzed sp3 C-H Alkylation of α-Olefins with Unactivated Alkyl Bromides",

abstract = "A light-induced redox-neutral Ni-catalyzed sp3 C-H alkylation of unactivated alkenes with alkyl bromides possessing β-hydrogens is described herein. The method is distinguished by its simplicity, wide scope, and exquisite regio- and chemoselectivity profile, thus offering an entry point to forge sp3-sp3 architectures.",

keywords = "Nickel, Photochemistry, Cross-coupling, Alkylation, Olefin functionalization",

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T1 - Redox-Neutral Ni-Catalyzed sp3 C-H Alkylation of α-Olefins with Unactivated Alkyl Bromides

AU - Buendia, Mikkel B.

AU - Higginson, Bradley

AU - Kegnæs, Søren

AU - Kramer, Søren

AU - Martin, Ruben

PY - 2022

Y1 - 2022

N2 - A light-induced redox-neutral Ni-catalyzed sp3 C-H alkylation of unactivated alkenes with alkyl bromides possessing β-hydrogens is described herein. The method is distinguished by its simplicity, wide scope, and exquisite regio- and chemoselectivity profile, thus offering an entry point to forge sp3-sp3 architectures.

AB - A light-induced redox-neutral Ni-catalyzed sp3 C-H alkylation of unactivated alkenes with alkyl bromides possessing β-hydrogens is described herein. The method is distinguished by its simplicity, wide scope, and exquisite regio- and chemoselectivity profile, thus offering an entry point to forge sp3-sp3 architectures.

KW - Nickel

KW - Photochemistry

KW - Cross-coupling

KW - Alkylation

KW - Olefin functionalization

U2 - 10.1021/acscatal.2c01057

DO - 10.1021/acscatal.2c01057

M3 - Letter

SN - 2155-5435

VL - 12

SP - 3815

EP - 3820

JO - ACS Catalysis

JF - ACS Catalysis

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