Recurrence in affective disorder: analyses with frailty models

Elisabeth Wreford Andersen, Lars Vedel Kessing, Per Kragh Andersen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The risk of recurrence in affective disorder is influenced by the number of prior episodes and by a person's tendency toward recurrence. Newly developed frailty models were used to estimate the effect of the number of episodes on the rate of recurrence, taking into account individual frailty toward recurrence. The study base was the Danish psychiatric case register of all hospital admissions for primary affective disorder in Denmark during 1971-1993. A total of 20,350 first-admission patients were discharged with a diagnosis of major affective disorder. For women with unipolar disorder and for all kinds of patients with bipolar disorder, the rate of recurrence was affected by the number of prior episodes even when the effect was adjusted for individual frailty toward recurrence. No effect of episodes but a large effect of the frailty parameter was found for unipolar men. The authors concluded that the risk of recurrence seems to increase with the number of episodes of bipolar affective disorder in general and for women with unipolar disorder. Am J Epidemiol 1999; 149:404-11.
Original languageEnglish
JournalAmerican Journal of Epidemiology
Volume149
Issue number5
Pages (from-to)404-411
Number of pages8
ISSN0002-9262
Publication statusPublished - 1999
Externally publishedYes

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