Recon 2.2: from reconstruction to model of human metabolism

Neil Swainston; Kieran Smallbone; Hooman Hefzi; Paul D. Dobson; Judy Brewer; Michael Hanscho; Daniel C. Zielinski; Kok Siong Ang; Natalie J. Gardiner; Jahir M. Gutierrez; Sarantos Kyriakopoulos; Meiyappan Lakshmanan; Shangzhong Li; Joanne K. Liu; Veronica S. Martínez; Camila A. Orellana; Lake Ee Quek; Alex Thomas; Juergen Zanghellini; Nicole Borth; Dong Yup Lee; Lars K. Nielsen; Douglas B. Kell; Nathan Lewis; Pedro Mendes

doi:10.1007/s11306-016-1051-4

Recon 2.2: from reconstruction to model of human metabolism

Neil Swainston, Kieran Smallbone, Hooman Hefzi, Paul D. Dobson, Judy Brewer, Michael Hanscho, Daniel C. Zielinski, Kok Siong Ang, Natalie J. Gardiner, Jahir M. Gutierrez, Sarantos Kyriakopoulos, Meiyappan Lakshmanan, Shangzhong Li, Joanne K. Liu, Veronica S. Martínez, Camila A. Orellana, Lake Ee Quek, Alex Thomas, Juergen Zanghellini, Nicole BorthDong Yup Lee, Lars K. Nielsen, Douglas B. Kell, Nathan Lewis, Pedro Mendes

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Abstract

The human genome-scale metabolic reconstruction details all known metabolic reactions occurring in humans, and thereby holds substantial promise for studying complex diseases and phenotypes. Capturing the whole human metabolic reconstruction is an on-going task and since the last community effort generated a consensus reconstruction, several updates have been developed.

Original language	English
Article number	109
Journal	Metabolomics
Volume	12
Number of pages	7
ISSN	1573-3882
DOIs	https://doi.org/10.1007/s11306-016-1051-4
Publication status	Published - 2016

Bibliographical note

The Author(s) 2016. This article is published with open access at Springerlink.com

Keywords

Human
Metabolism
Modelling
Reconstruction
Model
Systems biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Swainston, N., Smallbone, K., Hefzi, H., Dobson, P. D., Brewer, J., Hanscho, M., Zielinski, D. C., Ang, K. S., Gardiner, N. J., Gutierrez, J. M., Kyriakopoulos, S., Lakshmanan, M., Li, S., Liu, J. K., Martínez, V. S., Orellana, C. A., Quek, L. E., Thomas, A., Zanghellini, J., ... Mendes, P. (2016). Recon 2.2: from reconstruction to model of human metabolism. Metabolomics, 12, Article 109. https://doi.org/10.1007/s11306-016-1051-4

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title = "Recon 2.2: from reconstruction to model of human metabolism",

abstract = "The human genome-scale metabolic reconstruction details all known metabolic reactions occurring in humans, and thereby holds substantial promise for studying complex diseases and phenotypes. Capturing the whole human metabolic reconstruction is an on-going task and since the last community effort generated a consensus reconstruction, several updates have been developed.",

keywords = "Human, Metabolism, Modelling, Reconstruction, Model, Systems biology",

author = "Neil Swainston and Kieran Smallbone and Hooman Hefzi and Dobson, {Paul D.} and Judy Brewer and Michael Hanscho and Zielinski, {Daniel C.} and Ang, {Kok Siong} and Gardiner, {Natalie J.} and Gutierrez, {Jahir M.} and Sarantos Kyriakopoulos and Meiyappan Lakshmanan and Shangzhong Li and Liu, {Joanne K.} and Mart{\'i}nez, {Veronica S.} and Orellana, {Camila A.} and Quek, {Lake Ee} and Alex Thomas and Juergen Zanghellini and Nicole Borth and Lee, {Dong Yup} and Nielsen, {Lars K.} and Kell, {Douglas B.} and Nathan Lewis and Pedro Mendes",

note = "The Author(s) 2016. This article is published with open access at Springerlink.com ",

year = "2016",

doi = "10.1007/s11306-016-1051-4",

language = "English",

volume = "12",

journal = "Metabolomics",

issn = "1573-3882",

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Swainston, N, Smallbone, K, Hefzi, H, Dobson, PD, Brewer, J, Hanscho, M, Zielinski, DC, Ang, KS, Gardiner, NJ, Gutierrez, JM, Kyriakopoulos, S, Lakshmanan, M, Li, S, Liu, JK, Martínez, VS, Orellana, CA, Quek, LE, Thomas, A, Zanghellini, J, Borth, N, Lee, DY, Nielsen, LK, Kell, DB, Lewis, N & Mendes, P 2016, 'Recon 2.2: from reconstruction to model of human metabolism', Metabolomics, vol. 12, 109. https://doi.org/10.1007/s11306-016-1051-4

TY - JOUR

T1 - Recon 2.2

T2 - from reconstruction to model of human metabolism

AU - Swainston, Neil

AU - Smallbone, Kieran

AU - Hefzi, Hooman

AU - Dobson, Paul D.

AU - Brewer, Judy

AU - Hanscho, Michael

AU - Zielinski, Daniel C.

AU - Ang, Kok Siong

AU - Gardiner, Natalie J.

AU - Gutierrez, Jahir M.

AU - Kyriakopoulos, Sarantos

AU - Lakshmanan, Meiyappan

AU - Li, Shangzhong

AU - Liu, Joanne K.

AU - Martínez, Veronica S.

AU - Orellana, Camila A.

AU - Quek, Lake Ee

AU - Thomas, Alex

AU - Zanghellini, Juergen

AU - Borth, Nicole

AU - Lee, Dong Yup

AU - Nielsen, Lars K.

AU - Kell, Douglas B.

AU - Lewis, Nathan

AU - Mendes, Pedro

N1 - The Author(s) 2016. This article is published with open access at Springerlink.com

PY - 2016

Y1 - 2016

N2 - The human genome-scale metabolic reconstruction details all known metabolic reactions occurring in humans, and thereby holds substantial promise for studying complex diseases and phenotypes. Capturing the whole human metabolic reconstruction is an on-going task and since the last community effort generated a consensus reconstruction, several updates have been developed.

AB - The human genome-scale metabolic reconstruction details all known metabolic reactions occurring in humans, and thereby holds substantial promise for studying complex diseases and phenotypes. Capturing the whole human metabolic reconstruction is an on-going task and since the last community effort generated a consensus reconstruction, several updates have been developed.

KW - Human

KW - Metabolism

KW - Modelling

KW - Reconstruction

KW - Model

KW - Systems biology

U2 - 10.1007/s11306-016-1051-4

DO - 10.1007/s11306-016-1051-4

M3 - Journal article

C2 - 27358602

SN - 1573-3882

VL - 12

JO - Metabolomics

JF - Metabolomics

M1 - 109

ER -

Recon 2.2: from reconstruction to model of human metabolism

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

OpenUrl availability

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Cite this