Recombinant vaccines: experimental and applied aspects

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Development of vaccines for aquaculture fish represent an important applied functional aspect of fish immunology research. Particularly in the case of recombinant vaccines, where a single antigen is usually expected to induce immunity to a specific pathogen, knowledge of mechanisms involved in induction of a protective immune response may become vital. The few recombinant vaccines licensd so far, despite much research during the last decade, illustrate that this is not a straightforward matter. However, as vaccine technology as well as our knowledge of the fish immune system is steadily improved, these fields will open up a number of interesting research objectives of mutual benefit. Recent aspects of recombinant protein vaccines, live recombinant vaccines and DNA vaccines are discussed.
    Original languageEnglish
    JournalFish & shellfish immunology
    Volume9
    Issue number4
    Pages (from-to)361-365
    ISSN1050-4648
    Publication statusPublished - 1999

    Keywords

    • recombinant protein
    • safety
    • live vectors
    • DNA vaccine
    • gene technology
    • protective mechanisms

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