TY - JOUR
T1 - Recent trends in metabolic engineering of microbial chemical factories
AU - Liu, Yi-Lin
AU - Nielsen, Jens
PY - 2019
Y1 - 2019
N2 - Microbe-mediated chemical production can replace traditional fossil-dependent production and hereby ensure sustainable production of chemicals that are important for our society. Significant success in economical chemical bioproduction has been accomplished by improving the cellular properties of microbial cells through metabolic engineering. The emergence of new techniques and strategies has led to a significant reduction in the turnaround time in the classic design-build-test-learn (DBTL) cycle in metabolic engineering. Here, we summarize the recent achievements and trends in microbial production of chemicals, with a focus on biofuels and high-value natural compounds. In addition, we offer perspectives on the challenges and opportunities for the successful establishment of future microbial chemical factories.
AB - Microbe-mediated chemical production can replace traditional fossil-dependent production and hereby ensure sustainable production of chemicals that are important for our society. Significant success in economical chemical bioproduction has been accomplished by improving the cellular properties of microbial cells through metabolic engineering. The emergence of new techniques and strategies has led to a significant reduction in the turnaround time in the classic design-build-test-learn (DBTL) cycle in metabolic engineering. Here, we summarize the recent achievements and trends in microbial production of chemicals, with a focus on biofuels and high-value natural compounds. In addition, we offer perspectives on the challenges and opportunities for the successful establishment of future microbial chemical factories.
U2 - 10.1016/j.copbio.2019.05.010
DO - 10.1016/j.copbio.2019.05.010
M3 - Journal article
C2 - 31185380
SN - 0958-1669
VL - 60
SP - 188
EP - 197
JO - Current Opinion in Biotechnology
JF - Current Opinion in Biotechnology
ER -