Recent advances of metabolic engineering strategies in natural isoprenoid production using cell factories

Meijie Li, Feifei Hou, Tong Wu, Xinglin Jiang, Fuli Li, Haobao Liu, Mo Xian*, Haibo Zhang

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Covering: up to 2019As abundant natural products, isoprenoids have many useful industrial applications in the manufacturing of drugs, fragrances, food additives, colorants, rubber and advanced biofuels. The microbial production of isoprenoids has received much attention in recent years. Metabolic engineering approaches and synthetic biology have been utilized to reconstruct and optimize the metabolic pathways for isoprenoid production in cell factories. In this review, the recent advances in isoprenoid production using microbes are summarized, with a focus on MEP and MVA pathway engineering, downstream isoprenoid pathway engineering and microbial host engineering, which mainly includes central carbon pathway engineering. Finally, future perspectives for the improvement of isoprenoid production are discussed.
Original languageEnglish
JournalNatural Product Reports
ISSN0265-0568
DOIs
Publication statusAccepted/In press - 2020

Cite this

Li, Meijie ; Hou, Feifei ; Wu, Tong ; Jiang, Xinglin ; Li, Fuli ; Liu, Haobao ; Xian, Mo ; Zhang, Haibo. / Recent advances of metabolic engineering strategies in natural isoprenoid production using cell factories. In: Natural Product Reports. 2020.
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abstract = "Covering: up to 2019As abundant natural products, isoprenoids have many useful industrial applications in the manufacturing of drugs, fragrances, food additives, colorants, rubber and advanced biofuels. The microbial production of isoprenoids has received much attention in recent years. Metabolic engineering approaches and synthetic biology have been utilized to reconstruct and optimize the metabolic pathways for isoprenoid production in cell factories. In this review, the recent advances in isoprenoid production using microbes are summarized, with a focus on MEP and MVA pathway engineering, downstream isoprenoid pathway engineering and microbial host engineering, which mainly includes central carbon pathway engineering. Finally, future perspectives for the improvement of isoprenoid production are discussed.",
author = "Meijie Li and Feifei Hou and Tong Wu and Xinglin Jiang and Fuli Li and Haobao Liu and Mo Xian and Haibo Zhang",
year = "2020",
doi = "10.1039/c9np00016j",
language = "English",
journal = "Natural Product Reports",
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Recent advances of metabolic engineering strategies in natural isoprenoid production using cell factories. / Li, Meijie; Hou, Feifei; Wu, Tong; Jiang, Xinglin; Li, Fuli; Liu, Haobao; Xian, Mo; Zhang, Haibo.

In: Natural Product Reports, 2020.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Recent advances of metabolic engineering strategies in natural isoprenoid production using cell factories

AU - Li, Meijie

AU - Hou, Feifei

AU - Wu, Tong

AU - Jiang, Xinglin

AU - Li, Fuli

AU - Liu, Haobao

AU - Xian, Mo

AU - Zhang, Haibo

PY - 2020

Y1 - 2020

N2 - Covering: up to 2019As abundant natural products, isoprenoids have many useful industrial applications in the manufacturing of drugs, fragrances, food additives, colorants, rubber and advanced biofuels. The microbial production of isoprenoids has received much attention in recent years. Metabolic engineering approaches and synthetic biology have been utilized to reconstruct and optimize the metabolic pathways for isoprenoid production in cell factories. In this review, the recent advances in isoprenoid production using microbes are summarized, with a focus on MEP and MVA pathway engineering, downstream isoprenoid pathway engineering and microbial host engineering, which mainly includes central carbon pathway engineering. Finally, future perspectives for the improvement of isoprenoid production are discussed.

AB - Covering: up to 2019As abundant natural products, isoprenoids have many useful industrial applications in the manufacturing of drugs, fragrances, food additives, colorants, rubber and advanced biofuels. The microbial production of isoprenoids has received much attention in recent years. Metabolic engineering approaches and synthetic biology have been utilized to reconstruct and optimize the metabolic pathways for isoprenoid production in cell factories. In this review, the recent advances in isoprenoid production using microbes are summarized, with a focus on MEP and MVA pathway engineering, downstream isoprenoid pathway engineering and microbial host engineering, which mainly includes central carbon pathway engineering. Finally, future perspectives for the improvement of isoprenoid production are discussed.

U2 - 10.1039/c9np00016j

DO - 10.1039/c9np00016j

M3 - Journal article

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JO - Natural Product Reports

JF - Natural Product Reports

SN - 0265-0568

ER -