Recent advances in smart biotechnology: Hydrogels and nanocarriers for tailored bioactive molecules depot

Research output: Contribution to journalJournal article – Annual report year: 2017Researchpeer-review

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DOI

  • Author: Milcovich, Gesmi

    Italian Institute of Technology, Italy

  • Author: Lettieri, Stefania

    Italian Institute of Technology, Italy

  • Author: Antunes, Filipe E.

    University of Coimbra, Portugal

  • Author: Medronho, Bruno

    University of Algarve, Portugal

  • Author: Fonseca, Ana C.

    University of Coimbra, Portugal

  • Author: Coelho, Jorge F.J.

    University of Coimbra, Portugal

  • Author: Marizza, Paolo

    Nanoprobes, Department of Micro- and Nanotechnology, Technical University of Denmark, Denmark

  • Author: Perrone, Francesca

    University of Trieste, Italy

  • Author: Farra, Rossella

    University of Trieste, Italy

  • Author: Dapas, Barbara

    University of Trieste, Italy

  • Author: Grassi, Gabriele

    University of Trieste, Italy

  • Author: Grassi, Mario

    University of Trieste, Italy

  • Author: Giordani, Silvia

    Italian Institute of Technology, Italy

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Over the past ten years, the global biopharmaceutical market has remarkably grown, with ten over the top twenty worldwide high performance medical treatment sales being biologics. Thus, biotech R&D (research and development) sector is becoming a key leading branch, with expanding revenues. Biotechnology offers considerable advantages compared to traditional therapeutic approaches, such as reducing side effects, specific treatments, higher patient compliance and therefore more effective treatments leading to lower healthcare costs. Within this sector, smart nanotechnology and colloidal self-assembling systems represent pivotal tools able to modulate the delivery of therapeutics. A comprehensive understanding of the processes involved in the self-assembly of the colloidal structures discussed therein is essential for the development of relevant biomedical applications.In this review we report the most promising and best performing platforms for specific classes of bioactive molecules and related target, spanning from siRNAs, gene/plasmids, proteins/growth factors, small synthetic therapeutics and bioimaging probes.
Original languageEnglish
JournalAdvances in Colloid and Interface Science
Volume249
Pages (from-to)163-180
ISSN0001-8686
DOIs
Publication statusPublished - 2017
CitationsWeb of Science® Times Cited: No match on DOI

    Research areas

  • Bioactive molecule delivery, Carbon nano materials, Hydrogels, Liposomes, Micro/nanocarriers
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